| 释义 |
- Function
- As a drug target
- References
- Further reading
{{Infobox_gene}}Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.[1] Function Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.[2] In melanocytic cells DAPK1 gene expression may be regulated by MITF.[3] As a drug target Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.[4] This has not been demonstrated in actual patients. References 1. ^{{cite journal | vauthors = Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K | title = Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively | journal = Genomics | volume = 29 | issue = 1 | pages = 305–7 | date = Sep 1995 | pmid = 8530096 | pmc = | doi = 10.1006/geno.1995.1255 }}
2. ^{{cite web | title = Entrez Gene: DAPK1 death-associated protein kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1612| accessdate = }}
3. ^{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = Dec 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}
4. ^{{cite journal | vauthors = Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH | title = Death-associated protein kinase 1 promotes growth of p53-mutant cancers | journal = The Journal of Clinical Investigation | volume = 125 | issue = 7 | pages = 2707–20 | date = Jul 2015 | pmid = 26075823 | doi = 10.1172/JCI70805 | pmc=4563671}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A | title = Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death | journal = Genes & Development | volume = 9 | issue = 1 | pages = 15–30 | date = Jan 1995 | pmid = 7828849 | doi = 10.1101/gad.9.1.15 }}
- {{cite journal | vauthors = Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A | title = Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis | journal = Molecular and Cellular Biology | volume = 20 | issue = 3 | pages = 1044–54 | date = Feb 2000 | pmid = 10629061 | pmc = 85221 | doi = 10.1128/MCB.20.3.1044-1054.2000 }}
- {{cite journal | vauthors = Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB, Gallagher PJ | title = Identification of a new form of death-associated protein kinase that promotes cell survival | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39667–78 | date = Oct 2001 | pmid = 11485996 | pmc = 2823794 | doi = 10.1074/jbc.M101886200 }}
- {{cite journal | vauthors = Shohat G, Spivak-Kroizman T, Cohen O, Bialik S, Shani G, Berrisi H, Eisenstein M, Kimchi A | title = The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism | journal = The Journal of Biological Chemistry | volume = 276 | issue = 50 | pages = 47460–7 | date = Dec 2001 | pmid = 11579085 | doi = 10.1074/jbc.M105133200 }}
- {{cite journal | vauthors = Soria JC, Rodriguez M, Liu DD, Lee JJ, Hong WK, Mao L | title = Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers | journal = Cancer Research | volume = 62 | issue = 2 | pages = 351–5 | date = Jan 2002 | pmid = 11809677 | doi = }}
- {{cite journal | vauthors = Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S | title = Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis | journal = Haematologica | volume = 87 | issue = 6 | pages = 569–77 | date = Jun 2002 | pmid = 12031912 | doi = }}
- {{cite journal | vauthors = Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT | title = Patterns of gene promoter methylation in squamous cell cancer of the head and neck | journal = Oncogene | volume = 21 | issue = 27 | pages = 4231–6 | date = Jun 2002 | pmid = 12082610 | doi = 10.1038/sj.onc.1205528 }}
- {{cite journal | vauthors = Jin Y, Blue EK, Dixon S, Shao Z, Gallagher PJ | title = A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK | journal = The Journal of Biological Chemistry | volume = 277 | issue = 49 | pages = 46980–6 | date = Dec 2002 | pmid = 12351649 | pmc = 2824503 | doi = 10.1074/jbc.M208585200 }}
- {{cite journal | vauthors = Wang WJ, Kuo JC, Yao CC, Chen RH | title = DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals | journal = The Journal of Cell Biology | volume = 159 | issue = 1 | pages = 169–79 | date = Oct 2002 | pmid = 12370243 | pmc = 2173490 | doi = 10.1083/jcb.200204050 }}
- {{cite journal | vauthors = Nakatsuka S, Takakuwa T, Tomita Y, Hoshida Y, Nishiu M, Yamaguchi M, Nishii K, Yang WI, Aozasa K | title = Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T- and natural killer (NK)/T-cell malignancies | journal = Cancer Science | volume = 94 | issue = 1 | pages = 87–91 | date = Jan 2003 | pmid = 12708480 | doi = 10.1111/j.1349-7006.2003.tb01357.x }}
- {{cite journal | vauthors = Tian JH, Das S, Sheng ZH | title = Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 26265–74 | date = Jul 2003 | pmid = 12730201 | doi = 10.1074/jbc.M300492200 }}
- {{cite journal | vauthors = Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, Amiñoso C, De Campos JM, Isla A, Gutierrez M, Rey JA | title = Frequent death-associated protein-kinase promoter hypermethylation in brain metastases of solid tumors | journal = Oncology Reports | volume = 10 | issue = 4 | pages = 1031–3 | year = 2004 | pmid = 12792765 | doi = 10.3892/or.10.4.1031 }}
- {{cite journal | vauthors = Matsumoto H, Nagao M, Ogawa S, Kanehiro H, Hisanaga M, Ko S, Ikeda N, Fujii H, Koyama F, Mukogawa T, Nakajima Y | title = Prognostic significance of death-associated protein-kinase expression in hepatocellular carcinomas | journal = Anticancer Research | volume = 23 | issue = 2B | pages = 1333–41 | year = 2003 | pmid = 12820391 | doi = }}
- {{cite journal | vauthors = Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP | title = Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures | journal = Journal of Neurochemistry | volume = 86 | issue = 5 | pages = 1260–70 | date = Sep 2003 | pmid = 12911633 | doi = 10.1046/j.1471-4159.2003.01934.x }}
- {{cite journal | vauthors = Voso MT, Scardocci A, Guidi F, Zini G, Di Mario A, Pagano L, Hohaus S, Leone G | title = Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes | journal = Blood | volume = 103 | issue = 2 | pages = 698–700 | date = Jan 2004 | pmid = 14504087 | doi = 10.1182/blood-2003-07-2249 }}
- {{cite journal | vauthors = Jin Y, Gallagher PJ | title = Antisense depletion of death-associated protein kinase promotes apoptosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51587–93 | date = Dec 2003 | pmid = 14530257 | pmc = 2823796 | doi = 10.1074/jbc.M309165200 }}
- {{cite journal | vauthors = Kim WS, Son HJ, Park JO, Song SY, Park C | title = Promoter methylation and down-regulation of DAPK is associated with gastric atrophy | journal = International Journal of Molecular Medicine | volume = 12 | issue = 6 | pages = 827–30 | date = Dec 2003 | pmid = 14612952 | doi = 10.3892/ijmm.12.6.827 }}
- {{cite journal | vauthors = Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N | title = Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells | journal = Oncology Reports | volume = 11 | issue = 3 | pages = 661–5 | date = Mar 2004 | pmid = 14767518 | doi = 10.3892/or.11.3.661 }}
{{refend}}{{PDB Gallery|geneid=1612}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-9-stub}} 1 : EC 2.7.11 |