| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Deleted in azoospermia-like is a protein that in humans is encoded by the DAZL gene.[1] Function The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males.[2] Interactions DAZL has been shown to interact with DAZ1.[3][4] References 1. ^{{cite journal | vauthors = Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC | title = The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned | journal = Nature Genetics | volume = 14 | issue = 3 | pages = 292–9 | date = Nov 1996 | pmid = 8896558 | pmc = | doi = 10.1038/ng1196-292 }}
2. ^{{cite web | title = Entrez Gene: DAZL deleted in azoospermia-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1618| accessdate = }}
3. ^{{cite journal | vauthors = Ruggiu M, Cooke HJ | title = In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein | journal = Gene | volume = 252 | issue = 1–2 | pages = 119–26 | date = Jul 2000 | pmid = 10903443 | doi = 10.1016/S0378-1119(00)00219-5 }}
4. ^{{cite journal | vauthors = Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH | title = Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 | journal = Genomics | volume = 65 | issue = 3 | pages = 266–73 | date = May 2000 | pmid = 10857750 | doi = 10.1006/geno.2000.6169 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Shan Z, Hirschmann P, Seebacher T, Edelmann A, Jauch A, Morell J, Urbitsch P, Vogt PH | title = A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad | journal = Human Molecular Genetics | volume = 5 | issue = 12 | pages = 2005–11 | date = Dec 1996 | pmid = 8968755 | doi = 10.1093/hmg/5.12.2005 }}
- {{cite journal | vauthors = Yen PH, Chai NN, Salido EC | title = The human autosomal gene DAZLA: testis specificity and a candidate for male infertility | journal = Human Molecular Genetics | volume = 5 | issue = 12 | pages = 2013–7 | date = Dec 1996 | pmid = 8968756 | doi = 10.1093/hmg/5.12.2013 }}
- {{cite journal | vauthors = Seboun E, Barbaux S, Bourgeron T, Nishi S, Agulnik A, Egashira M, Nikkawa N, Bishop C, Fellous M, McElreavey K, Kasahara M, Algonik A | title = Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene | journal = Genomics | volume = 41 | issue = 2 | pages = 227–35 | date = Apr 1997 | pmid = 9143498 | doi = 10.1006/geno.1997.4635 }}
- {{cite journal | vauthors = Ruggiu M, Speed R, Taggart M, McKay SJ, Kilanowski F, Saunders P, Dorin J, Cooke HJ | title = The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis | journal = Nature | volume = 389 | issue = 6646 | pages = 73–7 | date = Sep 1997 | pmid = 9288969 | doi = 10.1038/37987 }}
- {{cite journal | vauthors = Chai NN, Phillips A, Fernandez A, Yen PH | title = A putative human male infertility gene DAZLA: genomic structure and methylation status | journal = Molecular Human Reproduction | volume = 3 | issue = 8 | pages = 705–8 | date = Aug 1997 | pmid = 9294855 | doi = 10.1093/molehr/3.8.705 }}
- {{cite journal | vauthors = Agulnik AI, Zharkikh A, Boettger-Tong H, Bourgeron T, McElreavey K, Bishop CE | title = Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations | journal = Human Molecular Genetics | volume = 7 | issue = 9 | pages = 1371–7 | date = Sep 1998 | pmid = 9700189 | doi = 10.1093/hmg/7.9.1371 }}
- {{cite journal | vauthors = Nishi S, Hoshi N, Kasahara M, Ishibashi T, Fujimoto S | title = Existence of human DAZLA protein in the cytoplasm of human oocytes | journal = Molecular Human Reproduction | volume = 5 | issue = 6 | pages = 495–7 | date = Jun 1999 | pmid = 10340994 | doi = 10.1093/molehr/5.6.495 }}
- {{cite journal | vauthors = Slee R, Grimes B, Speed RM, Taggart M, Maguire SM, Ross A, McGill NI, Saunders PT, Cooke HJ | title = A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 14 | pages = 8040–5 | date = Jul 1999 | pmid = 10393944 | pmc = 22184 | doi = 10.1073/pnas.96.14.8040 }}
- {{cite journal | vauthors = Dorfman DM, Genest DR, Reijo Pera RA | title = Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells | journal = Human Reproduction | volume = 14 | issue = 10 | pages = 2531–6 | date = Oct 1999 | pmid = 10527983 | doi = 10.1093/humrep/14.10.2531 }}
- {{cite journal | vauthors = Tsai MY, Chang SY, Lo HY, Chen IH, Huang FJ, Kung FT, Lu YJ | title = The expression of DAZL1 in the ovary of the human female fetus | journal = Fertility and Sterility | volume = 73 | issue = 3 | pages = 627–30 | date = Mar 2000 | pmid = 10689024 | doi = 10.1016/S0015-0282(99)00544-0 }}
- {{cite journal | vauthors = Brekhman V, Itskovitz-Eldor J, Yodko E, Deutsch M, Seligman J | title = The DAZL1 gene is expressed in human male and female embryonic gonads before meiosis | journal = Molecular Human Reproduction | volume = 6 | issue = 5 | pages = 465–8 | date = May 2000 | pmid = 10775651 | doi = 10.1093/molehr/6.5.465 }}
- {{cite journal | vauthors = Ruggiu M, Saunders PT, Cooke HJ | title = Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells | journal = Journal of Andrology | volume = 21 | issue = 3 | pages = 470–7 | year = 2000 | pmid = 10819456 | doi = }}
- {{cite journal | vauthors = Tsui S, Dai T, Warren ST, Salido EC, Yen PH | title = Association of the mouse infertility factor DAZL1 with actively translating polyribosomes | journal = Biology of Reproduction | volume = 62 | issue = 6 | pages = 1655–60 | date = Jun 2000 | pmid = 10819768 | doi = 10.1095/biolreprod62.6.1655 }}
- {{cite journal | vauthors = Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH | title = Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 | journal = Genomics | volume = 65 | issue = 3 | pages = 266–73 | date = May 2000 | pmid = 10857750 | doi = 10.1006/geno.2000.6169 }}
- {{cite journal | vauthors = Ruggiu M, Cooke HJ | title = In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein | journal = Gene | volume = 252 | issue = 1–2 | pages = 119–26 | date = Jul 2000 | pmid = 10903443 | doi = 10.1016/S0378-1119(00)00219-5 }}
- {{cite journal | vauthors = Reijo RA, Dorfman DM, Slee R, Renshaw AA, Loughlin KR, Cooke H, Page DC | title = DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice | journal = Biology of Reproduction | volume = 63 | issue = 5 | pages = 1490–6 | date = Nov 2000 | pmid = 11058556 | doi = 10.1095/biolreprod63.5.1490 }}
- {{cite journal | vauthors = Xu EY, Moore FL, Pera RA | title = A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7414–9 | date = Jun 2001 | pmid = 11390979 | pmc = 34683 | doi = 10.1073/pnas.131090498 }}
- {{cite journal | vauthors = Van Golde RJ, Tuerlings JH, Kremer JA, Braat DD, Schoute F, Hoefsloot LH | title = DAZLA: an important candidate gene in male subfertility? | journal = Journal of Assisted Reproduction and Genetics | volume = 18 | issue = 7 | pages = 395–9 | date = Jul 2001 | pmid = 11499325 | pmc = 3455824 | doi = 10.1023/A:1016678624225 }}
- {{cite journal | vauthors = Lin YM, Chen CW, Sun HS, Tsai SJ, Hsu CC, Teng YN, Lin JS, Kuo PL | title = Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men | journal = Molecular Human Reproduction | volume = 7 | issue = 11 | pages = 1015–22 | date = Nov 2001 | pmid = 11675467 | doi = 10.1093/molehr/7.11.1015 }}
{{refend}}{{gene-3-stub}} |