“Delta24(241)-sterol reductase”的意思、由来-开放百科全书

词条

Delta24(241)-sterol reductase

释义

References

{{enzyme
| Name = delta24(24-1) sterol reductase
| EC_number = 1.3.1.71
| CAS_number =
| IUBMB_EC_number = 1/3/1/71
| GO_code = 0000246
| image =
| width =
| caption =
}}

In enzymology, a Delta24(241)-sterol reductase ({{EC number|1.3.1.71}}) is an enzyme that catalyzes the chemical reaction

ergosterol + NADP⁺ ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H⁺

Thus, the two substrates of this enzyme are ergosterol and NADP⁺, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.

References

{{cite journal | vauthors = Neal WD, Parks LW | date = 1977 | title = Sterol 24(28) methylene reductase in Saccharomyces cerevisiae | journal = J. Bacteriol. | volume = 129 | pages = 1375–8 | pmid = 14922 | issue = 3 | pmc = 235112 }}
{{cite journal | vauthors = Zweytick D, Hrastnik C, Kohlwein SD, Daum G | date = 2000 | title = Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae | journal = FEBS Lett. | volume = 470 | pages = 83–7 | pmid = 10722850 | doi = 10.1016/S0014-5793(00)01290-4 | issue = 1 }}

3 : EC 1.3.1|NADPH-dependent enzymes|Enzymes of unknown structure

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