| 词条 | Demecarium bromide |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 460775208 | IUPAC_name = Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylammoniophenoxy)carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide | image = Demecarium bromide.svg | width = 300 | tradename = Humorsol | pregnancy_category = | legal_status = | routes_of_administration = Topical (ophthalmic solution) | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 56-94-0 | ATC_prefix = S01 | ATC_suffix = EB04 | ATC_supplemental = | PubChem = 5965 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00944 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5750 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 61D5V4OKTP | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00667 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 4391 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1200514 | C=32 | H=52 | Br=2 | N=4 | O=4 | molecular_weight = 716.588 g/mol | smiles = [Br-].[Br-].O=C(Oc1cccc(c1)[N+](C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)[N+](C)(C)C)C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = YHKBUDZECQDYBR-UHFFFAOYSA-L }}Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.[1] Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).[2] As demecarium irreversibly inhibits cholinesterase, it can be administered less frequently than reversible inhibitors, such as carbachol.[3] Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,[3] is no longer available,[4] although solutions of demecarium can be compounded.[5] Use in dogsWhen administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.[4] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.[4] See also
References1. ^{{cite book |editor1-last=Jeske |editor1-first=Arthur H. |title=Mosby's dental drug reference |date=2014 |publisher=Elsevier Mosby |location=St. Louis, Missouri |isbn=978-0-323-16916-5 |page=374 |edition=11th |url=https://books.google.com/books?id=OcU0AwAAQBAJ&pg=PR548 |chapter=Demecarium bromide}} {{Opthalmologicals}}{{Acetylcholine metabolism and transport modulators}}2. ^{{cite book |last1=Stein |first1=Harold A. |last2=Stein |first2=Raymond M. |last3=Freeman |first3=Melvin I. |title=Ophthalmic dictionary and vocabulary builder for eye care professionals |date=2012 |publisher=Jaypee Brothers Medical |location=New Delhi |isbn=9789350253656 |page=103 |edition=4th |url=https://books.google.com/books?id=-xnRmiZBzqwC&pg=PA103}} 3. ^{{cite book |last1=Edmunds |first1=Marilyn Winterton |last2=Mayhew |first2=Maren Stewart |title=Pharmacology for the primary care provider |date=2013 |publisher=Elsevier Health Sciences |isbn=978-0-323-08790-2 |page=174 |edition=4th |url=https://books.google.com/books?id=8FwdEsvnw8oC&pg=PA174}} 4. ^1 2 3 {{cite book |last1=Maggs |first1=David J. |last2=Miller |first2=Paul E. |last3=Ofri |first3=Ron |title=Slatter's Fundamentals of Veterinary Ophthalmology |date=2013 |publisher=Elsevier |location=St. Louis, Missouri |isbn=978-1-4377-2367-0 |page=51 |edition=5th |url=https://books.google.com/books?id=8QCduRN3zR0C&pg=PA51 |chapter=Indirect-acting parasympathomimetic agents}} 5. ^{{cite journal |last1=Alario |first1=AF |last2=Strong |first2=TD |last3=Pizzirani |first3=S |title=Medical treatment of primary canine glaucoma |journal=The Veterinary clinics of North America. Small animal practice |date=November 2015 |volume=45 |issue=6 |pages=1235-59, vi |doi=10.1016/j.cvsm.2015.06.004 |pmid=26319445}} 5 : Acetylcholinesterase inhibitors|Bromides|Biscarbamates|Quaternary ammonium compounds|Veterinary drugs |
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