“Deoxyribodipyrimidine photo-lyase”的意思、由来-开放百科全书

词条

Deoxyribodipyrimidine photo-lyase

释义

Structural studies
References

{{enzyme
| Name = deoxyribodipyrimidine photo-lyase
| EC_number = 4.1.99.3
| CAS_number = 37290-70-3
| IUBMB_EC_number = 4/1/99/3
| GO_code = 0003904
| image =
| width =
| caption =
}}

In enzymology, a deoxyribodipyrimidine photo-lyase ({{EC number|4.1.99.3}}) is an enzyme that catalyzes the chemical reaction

cyclobutadipyrimidine (in DNA) 2 pyrimidine residues (in DNA)

Hence, this enzyme has one substrate, cyclobutadipyrimidine (in DNA), and one product, pyrimidine residues (in DNA).

This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is deoxyribocyclobutadipyrimidine pyrimidine-lyase. Other names in common use include photoreactivating enzyme, DNA photolyase, DNA-photoreactivating enzyme, DNA cyclobutane dipyrimidine photolyase, DNA photolyase, deoxyribonucleic photolyase, deoxyribodipyrimidine photolyase, photolyase, PRE, PhrB photolyase, deoxyribonucleic cyclobutane dipyrimidine photolyase, phr A photolyase, dipyrimidine photolyase (photosensitive), and deoxyribonucleate pyrimidine dimer lyase (photosensitive). It has 2 cofactors: FAD, and 5,10-Methenyltetrahydrofolate.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1DNP}}, {{PDB link|1IQR}}, {{PDB link|1IQU}}, {{PDB link|1OWL}}, {{PDB link|1OWM}}, {{PDB link|1OWN}}, {{PDB link|1OWO}}, {{PDB link|1OWP}}, {{PDB link|1QNF}}, {{PDB link|1TEZ}}, {{PDB link|2E0I}}, {{PDB link|2J07}}, {{PDB link|2J08}}, and {{PDB link|2J09}}.

References

{{cite journal | vauthors = Eker AP, Fichtinger-Schepman AM | date = 1975 | title = Studies on a DNA photoreactivating enzyme from Streptomyces griseus II. Purification of the enzyme | journal = Biochim. Biophys. Acta | volume = 378 | pages = 54–63 | pmid = 804322 | issue = 1 | doi=10.1016/0005-2787(75)90136-7}}
{{cite journal | vauthors = Sancar GB, Smith FW, Reid R, Payne G, Levy M, Sancar A | date = 1987 | title = Action mechanism of Escherichia coli DNA photolyase. I. Formation of the enzyme-substrate complex | journal = J. Biol. Chem. | volume = 262 | pages = 478–85 | pmid = 3539939 | issue = 1 }}
{{cite journal | vauthors = Setlow JK, Bollum FJ | date = 1968 | title = The minimum size of the substrate for yeast photoreactivating enzyme | journal = Biochim. Biophys. Acta | volume = 157 | pages = 233–7 | pmid = 5649902 | issue = 2 | doi = 10.1016/0005-2787(68)90077-4 }}

3 : EC 4.1.99|Flavin enzymes|Enzymes of known structure

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