| 词条 | Dequalinium |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 460776976 | Name = Dequalinium chloride | ImageFile = Dequalinium chloride.png | ImageSize = | IUPACName = 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride | OtherNames = |Section1={{Chembox Identifiers | IUPHAR_ligand = 2313 | InChI = 1/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 | InChIKey = PCSWXVJAIHCTMO-SKRXCDHZAO | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PCSWXVJAIHCTMO-UHFFFAOYSA-P | CASNo_Ref = {{cascite|correct|??}} | CASNo = | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 31466 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 333826 | ChEMBL2_Ref = {{ebicite|correct|EBI}} | ChEMBL2 = 121663 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2886 | PubChem = 10649 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = E7QC7V26B8 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB04209 | SMILES = c12ccccc1c(cc([n+]2CCCCCCCCCC[n+]4c3ccccc3c(N)cc4C)C)N | MeSHName = Dequalinium |Section2={{Chembox Properties | C=30 | H=40 | N=4 | Cl=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section6={{Chembox Pharmacology | ATCCode_prefix = D08 | ATCCode_suffix = AH01 | ATC_Supplemental = {{ATC|G01|AC05}}, {{ATC|R02|AA02}} }} |Section7={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications: Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration. Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis and aerobic vaginitis). The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by an N-decylene chain. ApplicationsDequalinium salts may be used to treat malaria.[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections [2] References1. ^{{cite web | title=US Patent 4946849 | url=http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4946849.PN.&OS=PN/4946849&RS=PN/4946849 | publisher=United States Patents and Trademarks Office (USPTO) | date=10 October 1989 | accessdate=2008-03-15}} 2. ^{{cite journal | author = Krämer W. | language = German | title=[Treatment of tonsilitis with dequalinium chloride] | pmid = 856702 | journal=Fortschr. Med. | year = 1977 | volume = 95 | issue = 16 | pages = 1108–10}} Further reading
External links
3 : Quinolines|Quaternary ammonium compounds|Antiseptics |
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