| 词条 | Dienestrol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 460784619 | IUPAC_name = 4-[4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol | image = Dienestrol.svg | width = 250px | tradename = Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Cycladiene, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol | Drugs.com = {{drugs.com|CONS|dienestrol}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Nonsteroidal estrogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 7160 | CAS_number_Ref = {{cascite|changed|CAS}} | CAS_number = 13029-44-2 | ATC_prefix = G03 | ATC_suffix = CB01 | ATC_supplemental = {{ATC|G03|CC02}} | PubChem = 667476 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00890 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 580857 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = RRW32X4U1F | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00898 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 4518 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1018 | synonyms = Dienoestrol; p-[(E,E)-1-Ethylidene-2-(p-hydroxyphenyl)-2-butenyl]phenol; 3,4-Di(para-hydroxyphenyl)-2,4-hexadiene | C=18 | H=18 | O=2 | molecular_weight = 266.334 g/mol | SMILES = Oc2ccc(C(/C(c1ccc(O)cc1)=C/C)=C\\C)cc2 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+ | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = NFDFQCUYFHCNBW-SCGPFSFSSA-N }}Dienestrol ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others), also known as dienoestrol ({{abbrlink|BAN|British Approved Name}}), is a synthetic nonsteroidal estrogen of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe.[1][2][3][4] It has been studied for use by rectal administration in the treatment of prostate cancer in men as well.[5] The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.[4] Dienestrol is a close analogue of diethylstilbestrol.[6] It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively.[7]Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically.[2] See also
References1. ^{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA331|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=331–}} {{Estrogens and antiestrogens}}{{Estrogen receptor modulators}}{{Genito-urinary-drug-stub}}2. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA390|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=390–}} 3. ^{{cite book|author=Muller|title=European Drug Index: European Drug Registrations, Fourth Edition|url=https://books.google.com/books?id=2HBPHmclMWIC&pg=PA361|date=19 June 1998|publisher=CRC Press|isbn=978-3-7692-2114-5|pages=361–}} 4. ^1 {{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA1286|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=1286–}} 5. ^{{cite journal | vauthors = Sambuelli M | title = Somministrazione degli estrogeni per via rettale nel carcinoma prostatico. | trans-title = Rectal administration of estrogens in prostate carcinoma | language = Italian | journal = Minerva Urol | volume = 5 | issue = 1 | pages = 28–32 | date = 1953 | issn = 0026-4989 | pmid = 13063334 | doi = | url = }} 6. ^{{cite book|title=VITAMINS AND HORMONES|url=https://books.google.com/books?id=7PrzbzO-Q2AC&pg=PA233|date=1 January 1945|publisher=Academic Press|isbn=978-0-08-086600-0|pages=233–}} 7. ^{{cite journal | vauthors = Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA | title = Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta | journal = Endocrinology | volume = 138 | issue = 3 | pages = 863–70 | year = 1997 | pmid = 9048584 | doi = 10.1210/endo.138.3.4979 | url = }} 4 : Abandoned drugs|Phenols|Stilbenoids|Synthetic estrogens |
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