| 词条 | Dimenoxadol |
| 释义 |
| Watchedfields = changed | verifiedrevid = 447990763 | IUPAC_name = 2-(dimethylamino)ethyl 2-ethoxy-2,2-diphenylacetate | image = Dimenoxadol.svg | width = 180 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = S9 | legal_CA = Schedule I | legal_UK = | legal_US = Schedule I | legal_DE = Anlage I | legal_UN = P I | routes_of_administration = | bioavailability = | protein_bound = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 509-78-4 | ATC_prefix = none | ATC_suffix = | PubChem = 17036 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB01461 | ChEMBL = 2104309 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 16137 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 4D65PBX0VK | C=20 | H=25 | N=1 | O=3 | molecular_weight = 327.42 g/mol | smiles = Cl.CCOC(C(=O)OCCN(C)C)(c1ccccc1)c1ccccc1 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C20H25NO3/c1-4-24-20(17-11-7-5-8-12-17,18-13-9-6-10-14-18)19(22)23-16-15-21(2)3/h5-14H,4,15-16H2,1-3H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = RHUWRJWFHUKVED-UHFFFAOYSA-N | synonyms = Dimenoxadol, Estocin }} Dimenoxadol (INN) (brand name Estocin (in Russia)), or dimenoxadole (BAN), is an opioid analgesic which is a benzilic acid derivative, closely related to benactyzine (an anticholinergic). Further, the structure is similar to methadone and related compounds like dextropropoxyphene. It was invented in Germany in the 1950s,[1] and produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.[2][3][4] In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9617 and a 2013 annual aggregrate manufacturing quota of zero. References1. ^{{cite patent | country = GB | number = 716700 | title = A new and improved analgesic and process for its production | inventor = Boehringer, A et al. | pubdate = 10/13/1954}} {{Analgesics}}{{Opioidergics}}{{analgesic-stub}}2. ^{{Cite journal | last1 = Gorbatova | first1 = E. N. | title = The pharmacology of estocin, an new analgesic | journal = Stomatologiia | volume = 46 | issue = 2 | pages = 22–25 | year = 1967 | pmid = 5232927}} 3. ^{{Cite journal | last1 = Kingisepp | first1 = G. A. | last2 = Kurvits | first2 = K. | last3 = Nurmand | first3 = L. B. | title = Pharmacology of dimethylaminoethyl ester of diphenylethoxyacetic acid hydrochloride--estocin | journal = Farmakologiia i toksikologiia | volume = 32 | issue = 6 | pages = 710–712 | year = 1969 | pmid = 5381602}} 4. ^{{Cite journal | last1 = Liberman | first1 = S. S. | title = Analgesic action of estocin (dimethylaminoethyl ester hydrochloride of alpha, alpha-diphenylethoxyacetic acid) | journal = Farmakologiia i toksikologiia | volume = 31 | issue = 6 | pages = 668–671 | year = 1968 | pmid = 5729519}} 5 : Analgesics|Synthetic opioids|Ethers|Carboxylate esters|Mu-opioid agonists |
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