“Dimethylglycine oxidase”的意思、由来-开放百科全书

词条

Dimethylglycine oxidase

释义

Structural studies
References

{{enzyme
| Name = dimethylglycine oxidase
| EC_number = 1.5.3.10
| CAS_number = 74870-79-4
| IUBMB_EC_number = 1/5/3/10
| GO_code = 0047866
| image =
| width =
| caption =
}}

In enzymology, a dimethylglycine oxidase ({{EC number|1.5.3.10}}) is an enzyme that catalyzes the chemical reaction

N,N-dimethylglycine + H₂O + O₂ sarcosine + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N,N-dimethylglycine, H₂O, and O₂, whereas its 3 products are sarcosine, formaldehyde, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N,N-dimethylglycine:oxygen oxidoreductase (demethylating). It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB2|1PJ5}}, {{PDB2|1PJ6}}, and {{PDB2|1PJ7}}.

References

{{cite journal | vauthors = Mori N, Kawakami B, Tani Y, Yamada H | date = 1980 | title = Purification and properties of dimethylglycine oxidase from Cylindrocarpon didymum M-1 | journal = Agric. Biol. Chem. | volume = 44 | pages = 1383–1389 | doi=10.1271/bbb1961.44.1383}}

3 : EC 1.5.3|Flavin enzymes|Enzymes of known structure

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