Disquiet may refer to:

• Disquiet (Strugatsky novel), a 1965 sci-fi novel by Boris and Arkady Strugatsky
• Disquiet (Leigh novel), a 2008 novel by Julia Leigh
• Disquiet (Therapy? album), a 2015 album by Irish rock band Therapy?

• Christine of Hesse-Kassel (1578-1658)
• Christine of Mecklenburg-Gustrow
• Christine of the Hungry Heart
• Christine of the Isles
• Christine O'Keefe
• Christine Orengo
• Christine Orr
• Christine Ortiz
• Christine Ouinsavi
• Christine Ourmières-Widener
• Christine Pak
• Christine Palm
• Christine Palmer
• Christine Paul
• Christine Paulin-Mohring
• Christine Payne
• Christine P. Barber
• Christine Pellegrino
• Christine 'Peng Peng' Lee
• Christine Peng Peng Lee
• Christine Penmark
• Christine Pepelyan
• Christine Petit (swimmer)
• Christine Pfitzinger
• Christine Phillip