1. Medical uses

2. Procedure

3. Risks

4. History

5. Society and culture

6. Research directions

7. See also

8. Notes

Medical uses

Distraction osteogenesis (DO) is used in orthopedic surgery, podiatric surgery, and oral and maxillofacial surgery to repair skeletal deformities and in reconstructive surgery.^[1][2][3] It was originally used to treat problems like unequal leg length, but since the 1980s is most commonly used to treat issues like hemifacial microsomia, micrognathism (chin so small it causes health problems), craniofrontonasal dysplasias, craniosynostosis, as well as airway obstruction in babies caused by glossoptosis (tongue recessed too far back in the mouth) or micrognathism.^[1]

In 2016 a systematic review of papers describing bone and soft tissue outcomes of DO procedures on the lower jawbone was published; the authors had planned to do a meta-analysis but found the studies were too poor in quality and too heterogeneous to pool.^[4] From what they were able to generalize, the authors found there was significant relapse in the vertical plane for bone, and a higher risk of relapse when there was an initial high gonial angle or Jarabak ratio (sella–gonion/nasion–menton).^[4] For soft tissue, little evidence was available regarding the vertical dimension, while a 90% correspondence between skeletal and soft tissue was found for sagittal positioning; the dental-to-soft tissue agreement was around 20%.^[4]

A 2016 Cochrane review of DO on the upper jawbone to treat cleft lip and cleft palate compared with orthognathic surgery found only one study, involving 47 participants and performed between 2002 and 2008 at the University of Hong Kong.^[5]{{Update inline|reason=Updated version https://www.ncbi.nlm.nih.gov/pubmed/30095853|date = November 2018}} This was not sufficient evidence from which to generalize, but the authors noted that while both procedures produced notable hard and soft tissue improvements, the DO group had greater advancement of the maxillary and less horizontal relapse five years after surgery.^[5] There was no difference in speech or nasal emissions outcomes nor in adverse effects; the DO group had lower satisfaction at three months after surgery but higher at two years.^[5]

Procedure

In the first phase, called the "osteotomy/surgical phase", the bone is cut, either partially, only through the hard exterior, or completely, and a device is fitted which will be used in the next phases. In the second phase, the latency period, which lasts generally seven days, the appliance is not activated and early stages of bone healing are allowed. In the third phase, the "distraction phase", the device, which is mounted to the bone on each side of the cut, is used to gradually separate the two pieces, allowing new bone to form in the gap. When the desired or possible length is reached, which usually takes three to seven days, a consolidation phase follows in which the device keeps the bone stable to allow the bone to fully heal. After the consolidation phase, the device is removed in a second surgical procedure.^[1]

The device that is used is usually manually operated by twisting a rod that through a rack and pinion system or the like, separates the bone; the rate of separation is carefully determined because going too quickly can cause nonunion, in which unstable fibrous connective tissue is formed instead of bone, and going too slowly can allow premature union to occur. Generally the rate is about a millimeter per day, achieved in two steps per day. The frequency of steps and how much the device is moved at each step, is called the "rhythm". The devices sometimes contain a spring that provides tension to continually separate the bones, instead of being manually operated at set intervals.^[1]

Despite these manually operated systems there are also motorized systems like the FITBONE from WITTENSTEIN. The FITBONE is a fully implantable, motorized, lengthening and correction nail.^[6] Advantages of this device are accurate deformity correction, low scar tissue formation, and reduced risk of infection.^[7][8] Furthermore the patients describe the procedure as more comfortable than limb lengthening with mechanical systems.^[9]

Risks

Risks include infection (5% overall, with 1% of those requiring pin removal and the bone becoming infected in .5%), failure for bone to grow in the desired direction (between 7 and 9%), hardware failure (between 3 and 4.5%), failure to follow the distraction protocol (4.5% overall; too slow 2% and too fast .5%), 1% pain due to distraction ending the procedure; damage to the inferior alveolar nerve occurs in 3.5% of mandibular distraction, tooth bud injury in 2%, and facial nerve injury in 0.5% of cases.^[1]

History

The procedure was first proposed by Bernhard von Langenbeck in 1869, but the first publication of efforts to implement it clinically was by Alessandro Codivilla in 1905.^[1] The paper presented the results of efforts to treat 26 people who were born with malformed legs; Codivilla cut the femur, put a pin in the heel bone, and applied traction to each person.^[1][10] His paper showed high levels of complications, including infection, tissue death, and bones that failed to join, and his methods were not adopted.^[1]

The Russian orthopedic surgeon Gavriil Ilizarov studied DO methods in over 15,000 people starting in the 1950s; he developed external fixation devices and methods to separate severed leg bones gradually, and using them he determined optimal rates of separation. His work led to widespread use of DO.^[1][2]

The first use in the jaw was pioneered by Wolfgang Rosenthal in 1930 but it was not further explored until the 1980s; the first paper of the modern era describing clinical use was published in 1992.^[1][11]

Society and culture

In China in the early 2000s after economic reform and especially following the privatization of many sectors of the economy, a fad for cosmetic surgery swept China, which included some people undergoing distraction osteogenesis solely to become taller; Chinese media often featured stories in which people ended up with weak bones or splayed feet as a result.^[12]

Research directions

As of 2016 work was underway developing devices and techniques that would allow DO in more directions simultaneously.^[13]

As of 2013 work was underway on distraction devices using Shape-memory alloy that could precisely separate bone without the need for intervention, as well as springs and motors; the use of biopharmaceuticals like BMP in combination with devices was also being explored.^[14]

See also

• Bone grafting
• Fibrocartilage callus
• National Organization of Short Statured Adults (NOSSA)
• Tissue expansion
• Valgus deformity

Notes

• Castle of Opprebais
• Castle of Orval
• Castle of Ourém
• Castle of Paderne
• Castle of Park
• Castle of Penela (Portugal)
• Castle of Peracense
• Castle of Peralada
• Castle of Perk
• Castle of Peñafiel
• Castle of Pinhel
• Castle of Piétrebais
• Castle of Poeke
• Castle of Poilvache
• Castle of Popov
• Castle of Poppi
• Castle of Portalegre
• Castle of Presule
• Castle of Prösels
• Castle of Pubol
• Castle of Quirini
• Castle of racconigi
• Castle of Rameyen
• Castle of Rapperswil
• Castle of rattray