| 词条 | DMCM |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449580057 | ImageFile = DMCM.svg | ImageFile1 = DMCM3d.png | ImageSize = | IUPACName = Methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[5,4-b]indole-3-carboxylate | OtherNames = DMCM |Section1 = {{Chembox Identifiers | IUPHAR_ligand = 4179 | CASNo_Ref = {{cascite|correct|??}} | CASNo = 82499-00-1 | PubChem = 104999 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 94746 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,19H,5H2,1-4H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = GADIKQPUNWAMEB-UHFFFAOYSA-N | SMILES = CCC1=C2C3=CC(=C(C=C3NC2=CN=C1C(=O)OC)OC)OC | Section2 = {{Chembox Properties | Formula = C17H18N2O4 | MolarMass = 314.336 g/mol | Appearance = | Density = | MeltingPtC = | BoilingPtC = 87 | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}DMCM (methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a negative allosteric modulator of GABAA receptors, meaning that it causes the opposite effects to the benzodiazepine class of drugs. As such, DMCM has anxiogenic and convulsant properties,[1] and is used in scientific research to induce anxiety so that new anxiolytic medications can be tested,[2] and to produce convulsions so that anticonvulsant medications can be tested.[3][4][5] It has also been shown to produce analgesic effects in animals, thought to be because it produces panic which reduces the perception of pain.[6] See also
References1. ^{{cite journal | last1 = Contó | first1 = MB | last2 = De Carvalho | first2 = JG | last3 = Benedito | first3 = MA | title = Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist | journal = Pharmacology Biochemistry and Behavior | volume = 82 | issue = 3 | pages = 417–26 | year = 2005 | pmid = 16297441 | doi = 10.1016/j.pbb.2005.09.012 }} {{Convulsants}}{{GABA receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal | last1 = Cole | first1 = BJ | last2 = Hillmann | first2 = M | last3 = Seidelmann | first3 = D | last4 = Klewer | first4 = M | last5 = Jones | first5 = GH | title = Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat | journal = Psychopharmacology | volume = 121 | issue = 1 | pages = 118–26 | year = 1995 | pmid = 8539336 | doi=10.1007/BF02245598}} 3. ^{{cite journal | last1 = Brodie | first1 = MJ | title = Tiagabine pharmacology in profile | journal = Epilepsia | volume = 36 Suppl 6 | pages = S7–S9 | year = 1995 | pmid = 8595791 | doi=10.1111/j.1528-1157.1995.tb06015.x}} 4. ^{{cite journal | last1 = De Sarro | first1 = G | last2 = Chimirri | first2 = A | last3 = McKernan | first3 = R | last4 = Quirk | first4 = K | last5 = Giusti | first5 = P | last6 = De Sarro | first6 = A | title = Anticonvulsant activity of azirino1,2-d1,4benzodiazepines and related 1,4-benzodiazepines in mice | journal = Pharmacology Biochemistry and Behavior | volume = 58 | issue = 1 | pages = 281–9 | year = 1997 | pmid = 9264104 | doi=10.1016/S0091-3057(96)00565-5}} 5. ^{{cite journal | last1 = Leppä | first1 = E | last2 = Vekovischeva | first2 = OY | last3 = Lindén | first3 = AM | last4 = Wulff | first4 = P | last5 = Oberto | first5 = A | last6 = Wisden | first6 = W | last7 = Korpi | first7 = ER | title = Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice | journal = Neuropharmacology | volume = 48 | issue = 4 | pages = 469–78 | year = 2005 | pmid = 15755475 | doi = 10.1016/j.neuropharm.2004.11.007 }} 6. ^{{cite journal | last1 = Sieve | first1 = AN | last2 = King | first2 = TE | last3 = Ferguson | first3 = AR | last4 = Grau | first4 = JW | last5 = Meagher | first5 = MW | title = Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats | journal = Psychopharmacology | volume = 153 | issue = 2 | pages = 180–90 | year = 2001 | pmid = 11205417 | doi=10.1007/s002130000535}} 7 : Anxiogenics|Beta-Carbolines|Carboxylate esters|Convulsants|GABAA receptor negative allosteric modulators|Phenol ethers|Methyl esters |
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