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词条 DNQX
释义

  1. See also

  2. References

  3. External links

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 460112258
| Name =
| ImageFile = DNQX.png
| ImageSize = 180
| ImageAlt = Skeletal formula
| ImageFile1 = DNQX molecule spacefill.png
| ImageSize1 = 180
| ImageAlt1 = Space-filling model of DNQX
| IUPACName = 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
| OtherNames =
| SystematicName =
| Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3123097
| PubChem = 3899541
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL =
| InChI = 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
| InChIKey = RWVIMCIPOAXUDG-UHFFFAOYSA-N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = RWVIMCIPOAXUDG-UHFFFAOYSA-N
| CASNo_Ref = {{cascite|changed|??}}
| CASNo=2379-57-9
| UNII = 62T278S1MX
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB03759
| SMILES = O=c2[nH]c1cc(N(=O)=O)c(N(=O)=O)cc1[nH]c2=O
}}
| Section2 = {{Chembox Properties
| C=8 | H=4 | N=4 | O=6
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
| Section3 = {{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
| Section4 =
| Section5 =
| Section6 =
}}

DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies.[1] It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.

See also

  • Quinoxalinedione
  • CNQX

References

1. ^{{cite journal | vauthors = Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R | title = Glutamate receptor ion channels: structure, regulation, and function | journal = Pharmacological Reviews | volume = 62 | issue = 3 | pages = 405–96 | date = September 2010 | pmid = 20716669 | pmc = 2964903 | doi = 10.1124/pr.109.002451 }}

External links

  • DNQX MSDS
{{Ionotropic glutamate receptor modulators}}{{biochem-stub}}

7 : AMPA receptor antagonists|Kainate receptor antagonists|NMDA receptor antagonists|Nitro compounds|Quinoxalines|Quinones|Lactams

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