“D-proline reductase (dithiol)”的意思、由来-开放百科全书

词条

D-proline reductase (dithiol)

释义

References

{{enzyme
| Name = D-proline reductase (dithiol)
| EC_number = 1.21.4.1
| CAS_number = 37255-43-9
| IUBMB_EC_number = 1/21/4/1
| GO_code = 0050002
| image =
| width =
| caption =
}}

In enzymology, a D-proline reductase (dithiol) ({{EC number|1.21.4.1}}) is an enzyme that catalyzes the chemical reaction

5-aminopentanoate + lipoate D-proline + dihydrolipoate

Thus, the two substrates of this enzyme are 5-aminopentanoate and lipoate, whereas its two products are D-proline and dihydrolipoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with a disulfide as acceptor. The systematic name of this enzyme class is 5-aminopentanoate:lipoate oxidoreductase (cyclizing). This enzyme participates in arginine and proline metabolism. It employs one cofactor, pyruvate.

References

{{cite journal |vauthors=Hodgins DS, Abeles RH | date = 1969 | title = Studies of the mechanism of action of D-proline reductase: the presence on covalently bound pyruvate and its role in the catalytic process | journal = Arch. Biochem. Biophys. | volume = 130 | pages = 274–85 | pmid = 5778643 | doi = 10.1016/0003-9861(69)90034-4 | issue = 1 }}
{{cite journal |vauthors=Stadtman TC, Elliott P| date = 1957 | title = Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii | journal = J. Biol. Chem. | volume = 228 | pages = 983–997 |pmid=13475375}}
{{cite journal | author = JR, Pich A | date = 1999 | title = Identification of D-proline reductase from Clostridium sticklandii as a selenoenzyme and indications for a catalytically active pyruvoyl group derived from a cysteine residue by cleavage of a proprotein | journal = J. Biol. Chem. | volume = 274 | pages = 8445–54 | pmid = 10085076 | doi = 10.1074/jbc.274.13.8445 | last2 = Gräntzdörffer | first2 = A | last3 = Schierhorn | first3 = A | last4 = Rücknagel | first4 = KP | last5 = Andreesen | first5 = JR | last6 = Pich | first6 = A | issue = 13 }}

3 : EC 1.21.4|Pyruvate enzymes|Enzymes of unknown structure

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