| 词条 | DU145 |
| 释义 |
The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy.[2] DU145 are not hormone-sensitive and do not express prostate-specific antigen (PSA). DU145 cells have moderate metastatic potential compared to PC3 cells, which have high metastatic potential.[3] DU145 cells are androgen receptor positive.[4] References1. ^1 {{cite journal |vauthors=Alimirah F, Chen J, Basrawala Z, Xin H, Choubey D |title=DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation |journal=FEBS Lett. |volume=580 |issue=9 |pages=2294–300 |date=April 2006 |pmid=16580667 |doi=10.1016/j.febslet.2006.03.041 |url=}} 2. ^{{cite journal |vauthors=Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF |title=Isolation of a human prostate carcinoma cell line (DU 145) |journal=Int. J. Cancer |volume=21 |issue=3 |pages=274–81 |date=March 1978 |pmid=631930 |doi= 10.1002/ijc.2910210305|url=}} 3. ^{{cite journal |vauthors=Pulukuri SM, Gondi CS, Lakka SS |title=RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo |journal=J. Biol. Chem. |volume=280 |issue=43 |pages=36529–40 |date=October 2005 |pmid=16127174 |pmc=1351057 |doi=10.1074/jbc.M503111200 |display-authors=etal}} 4. ^{{cite journal|title=DU‐145 and PC‐3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation|date=24 March 2006|first1=Fatouma |last1=Alimirah|display-authors=etal|doi=10.1016/j.febslet.2006.03.041 |pmid=16580667|journal=FEBS Letters|volume=580|issue=9|pages=2294–2300}} External links
4 : Human cell lines|Cancer research|Urology|Prostate cancer |
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