“D-xylulose reductase”的意思、由来-开放百科全书

词条

D-xylulose reductase

释义

Structural studies
References

{{enzyme
| Name = D-xylulose reductase
| EC_number = 1.1.1.9
| CAS_number = 9028-16-4
| IUBMB_EC_number = 1/1/1/9
| GO_code = 0046526
| image =
| width =
| caption =
}}

In enzymology, a D-xylulose reductase ({{EC number|1.1.1.9}}) is an enzyme that catalyzes the chemical reaction

xylitol + NAD⁺ D-xylulose + NADH + H⁺

Thus, the two substrates of this enzyme are xylitol and NAD⁺, whereas its 3 products are D-xylulose, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is xylitol:NAD⁺ 2-oxidoreductase (D-xylulose-forming). Other names in common use include NAD⁺-dependent xylitol dehydrogenase, xylitol dehydrogenase, erythritol dehydrogenase, 2,3-cis-polyol(DPN) dehydrogenase (C3-5), pentitol-DPN dehydrogenase, and xylitol-2-dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1ZEM}}.

References

{{cite journal |vauthors=Chiang C, Knight SG | year = 1960 | title = A new pathway of pentose metabolism | journal = Biochem. Biophys. Res. Commun. | volume = 3 | pages = 554–9 | pmid = 13692998 | doi = 10.1016/0006-291X(60)90174-1 | issue = 5 }}
{{cite journal |author1 = Hickman J |author2 =Ashwell G | year = 1959 | title = A sensitive and stereospecific enzymatic assay for xylulose | journal = J. Biol. Chem. | volume = 234 | pages = 758–761 }}
{{cite journal |vauthors=Jakoby WB, Fredericks J | year = 1961 | title = Erythritol dehydrogenase from Aerobacter aerogenes | journal = Biochim. Biophys. Acta | volume = 48 | pages = 26–32 | pmid = 13789254 | doi = 10.1016/0006-3002(61)90511-X }}

{{Alcohol oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:D-Xylulose Reductase}}{{1.1.1-enzyme-stub}}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of known structure

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