E127 may refer to:

• E127 series, a Japanese train type
• Erythrosine, a food additive
• Ikarus E127, a Hungarian low-floor suburban bus
• European route E127 in Siberia and Kazakhstan

• Self-propelled vehicle
• Self-propulsion
• Self-Protect High-Energy Laser Demonstrator
• Self-Protection Squads
• Self Publish, Be Happy
• Self-published books
• Self-Published Fantasy Blog-Off
• Self-Publishing Review
• Self-Realization Fellowship Temple
• Self-reference lemma
• Self-referential machine learning
• Self-referential paradoxes
• Self-registering theodolite
• Self-regulating heater
• Self-relocate to load address
• Self-relocating
• Self-relocating boot loader
• Self-relocating bootloader
• Self-relocating code
• Self-relocating device driver
• Self-relocating driver
• Self-relocating driver program
• Self-relocating program
• Self-relocating RSX
• Self-relocating software