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词条 E2F1
释义

  1. Function

  2. Transcription

  3. Interactions

  4. See also

  5. References

  6. Further reading

  7. External links

{{Technical|date=December 2018}}{{Infobox_gene}}Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.[1]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.[2]

Transcription

E2F1 promoter[PAX8] => E2F1 {{PMID|21602887}}

Interactions

E2F1 has been shown to interact with:

{{div col|colwidth=20em}}
  • ARID3A,[3]
  • CUL1,[4]
  • Cyclin A1,[4]
  • Cyclin A2,[5]
  • GTF2H1,[6]
  • MDM4,[7]
  • NCOA6,[8]
  • NDN,[10][9]
  • NPDC1,[10]
  • PURA,[11]
  • PHB,[12][13][14][15]
  • RB1,[16][19][17][18][19][20][21]
  • RBL1,[22]
  • SKP2,[23]
  • SP1,[27][24][25]
  • SP2,[26]
  • SP3,[26]
  • SP4,[26]
  • TFDP1[3][21][27][28]
  • TOPBP1,[29][30]
  • TP53BP1,[19] and
  • UBC.[31]
{{Div col end}}

See also

  • E2F
  • Retinoblastoma protein
{{Clear}}

References

1. ^{{cite journal | vauthors = Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG | title = Structure and partial genomic sequence of the human E2F1 gene | journal = Gene | volume = 173 | issue = 2 | pages = 163–9 | date = December 1996 | pmid = 8964493 | pmc = | doi = 10.1016/0378-1119(96)00184-9 }}
2. ^{{Cite web| title = Entrez Gene: E2F1 E2F transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1869| accessdate = }}
3. ^1 {{cite journal | vauthors = Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K | title = A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer | journal = Oncogene | volume = 17 | issue = 7 | pages = 853–65 | date = August 1998 | pmid = 9780002 | doi = 10.1038/sj.onc.1202163 }}
4. ^{{cite journal | vauthors = Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP | title = Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2400–7 | date = March 1999 | pmid = 10022926 | pmc = 84032 | doi = 10.1128/mcb.19.3.2400}}
5. ^{{cite journal | vauthors = Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H | title = Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation | journal = Mol. Cell. Biol. | volume = 14 | issue = 12 | pages = 8420–31 | date = December 1994 | pmid = 7969176 | pmc = 359381 | doi = }}
6. ^{{cite journal | vauthors = Vandel L, Kouzarides T | title = Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase | journal = EMBO J. | volume = 18 | issue = 15 | pages = 4280–91 | date = August 1999 | pmid = 10428966 | pmc = 1171504 | doi = 10.1093/emboj/18.15.4280 }}
7. ^{{cite journal | vauthors = Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ | title = The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein | journal = J. Cell. Biochem. | volume = 88 | issue = 3 | pages = 557–68 | date = February 2003 | pmid = 12532331 | doi = 10.1002/jcb.10318 }}
8. ^{{cite journal | vauthors = Kong HJ, Yu HJ, Hong S, Park MJ, Choi YH, An WG, Lee JW, Cheong J | title = Interaction and functional cooperation of the cancer-amplified transcriptional coactivator activating signal cointegrator-2 and E2F-1 in cell proliferation | journal = Mol. Cancer Res. | volume = 1 | issue = 13 | pages = 948–58 | date = November 2003 | pmid = 14638867 | doi = }}
9. ^{{cite journal | vauthors = Kuwako K, Taniura H, Yoshikawa K | title = Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor | journal = J. Biol. Chem. | volume = 279 | issue = 3 | pages = 1703–12 | date = January 2004 | pmid = 14593116 | doi = 10.1074/jbc.M308454200 }}
10. ^{{cite journal | vauthors = Sansal I, Dupont E, Toru D, Evrard C, Rouget P | title = NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity | journal = Oncogene | volume = 19 | issue = 43 | pages = 5000–9 | date = October 2000 | pmid = 11042687 | doi = 10.1038/sj.onc.1203843 }}
11. ^{{cite journal | vauthors = Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Giordano A, Khalili K | title = Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1 | journal = Oncogene | volume = 18 | issue = 46 | pages = 6398–402 | date = November 1999 | pmid = 10597240 | doi = 10.1038/sj.onc.1203011 }}
12. ^{{cite journal | vauthors = Joshi B, Ko D, Ordonez-Ercan D, Chellappan SP | title = A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 312 | issue = 2 | pages = 459–66 | date = December 2003 | pmid = 14637159 | doi = 10.1016/j.bbrc.2003.10.148}}
13. ^{{cite journal | vauthors = Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S | title = Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47853–61 | date = November 2003 | pmid = 14500729 | doi = 10.1074/jbc.M305171200 }}
14. ^{{cite journal | vauthors = Wang S, Zhang B, Faller DV | title = Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth | journal = EMBO J. | volume = 21 | issue = 12 | pages = 3019–28 | date = June 2002 | pmid = 12065415 | pmc = 126057 | doi = 10.1093/emboj/cdf302 }}
15. ^{{cite journal | vauthors = Wang S, Nath N, Fusaro G, Chellappan S | title = Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7447–60 | date = November 1999 | pmid = 10523633 | pmc = 84738 | doi = 10.1128/mcb.19.11.7447}}
16. ^1 {{cite journal | vauthors = Taniura H, Taniguchi N, Hara M, Yoshikawa K | title = Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1 | journal = J. Biol. Chem. | volume = 273 | issue = 2 | pages = 720–8 | date = January 1998 | pmid = 9422723 | doi = 10.1074/jbc.273.2.720}}
17. ^{{cite journal | vauthors = Nicolas E, Ait-Si-Ali S, Trouche D | title = The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein | journal = Nucleic Acids Res. | volume = 29 | issue = 15 | pages = 3131–6 | date = August 2001 | pmid = 11470869 | pmc = 55834 | doi = 10.1093/nar/29.15.3131}}
18. ^{{cite journal | vauthors = Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM | title = MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation | journal = J. Biol. Chem. | volume = 277 | issue = 52 | pages = 50860–6 | date = December 2002 | pmid = 12397079 | doi = 10.1074/jbc.M203839200 }}
19. ^1 {{cite journal | vauthors = Choubey D, Li SJ, Datta B, Gutterman JU, Lengyel P | title = Inhibition of E2F-mediated transcription by p202 | journal = EMBO J. | volume = 15 | issue = 20 | pages = 5668–78 | date = October 1996 | pmid = 8896460 | pmc = 452311 | doi = }}
20. ^{{cite journal | vauthors = Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C | title = pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 14 | pages = 7738–43 | date = July 2000 | pmid = 10869426 | pmc = 16614 | doi = 10.1073/pnas.130198397 }}
21. ^1 {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2536–46 | date = May 1995 | pmid = 7739537 | pmc = 230484 | doi = 10.1128/mcb.15.5.2536}}
22. ^1 {{cite journal | vauthors = Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K | title = Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 | journal = J. Virol. | volume = 67 | issue = 12 | pages = 7641–7 | date = December 1993 | pmid = 8230483 | pmc = 238233 | doi = }}
23. ^1 {{cite journal | vauthors = Marti A, Wirbelauer C, Scheffner M, Krek W | title = Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation | journal = Nat. Cell Biol. | volume = 1 | issue = 1 | pages = 14–9 | date = May 1999 | pmid = 10559858 | doi = 10.1038/8984 }}
24. ^{{cite journal | vauthors = Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC | title = Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1668–75 | date = April 1996 | pmid = 8657142 | pmc = 231153 | doi = }}
25. ^{{cite journal | vauthors = Karlseder J, Rotheneder H, Wintersberger E | title = Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1659–67 | date = April 1996 | pmid = 8657141 | pmc = 231152 | doi = 10.1128/mcb.16.4.1659}}
26. ^1 2 3 {{cite journal | vauthors = Rotheneder H, Geymayer S, Haidweger E | title = Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter | journal = J. Mol. Biol. | volume = 293 | issue = 5 | pages = 1005–15 | date = November 1999 | pmid = 10547281 | doi = 10.1006/jmbi.1999.3213 }}
27. ^{{cite journal | vauthors = Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA | title = E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 6 | pages = 2403–7 | date = March 1995 | pmid = 7892279 | pmc = 42492 | doi = 10.1073/pnas.92.6.2403}}
28. ^{{cite journal | vauthors = Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E | title = Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation | journal = Genes Dev. | volume = 7 | issue = 10 | pages = 1850–61 | date = October 1993 | pmid = 8405995 | doi = 10.1101/gad.7.10.1850}}
29. ^{{cite journal | vauthors = Liu K, Lin FT, Ruppert JM, Lin WC | title = Regulation of E2F1 by BRCT domain-containing protein TopBP1 | journal = Mol. Cell. Biol. | volume = 23 | issue = 9 | pages = 3287–304 | date = May 2003 | pmid = 12697828 | pmc = 153207 | doi = 10.1128/mcb.23.9.3287-3304.2003}}
30. ^{{cite journal | vauthors = Yu X, Chini CC, He M, Mer G, Chen J | title = The BRCT domain is a phospho-protein binding domain | journal = Science | volume = 302 | issue = 5645 | pages = 639–42 | date = October 2003 | pmid = 14576433 | doi = 10.1126/science.1088753 }}
31. ^{{cite journal | vauthors = Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y | title = The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation | journal = J. Biol. Chem. | volume = 283 | issue = 21 | pages = 14506–15 | date = May 2008 | pmid = 18367454 | doi = 10.1074/jbc.M706136200 }}

Further reading

{{Refbegin|35em}}
  • {{cite journal | vauthors = Dupont E, Sansal I, Toru D, Evrard C, Rouget P | title = [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors] | journal = C. R. Séances Soc. Biol. Fil. | volume = 191 | issue = 1 | pages = 95–104 | year = 1997 | pmid = 9181131 | doi = }}
  • {{cite journal | vauthors = Stevens C, La Thangue NB | title = The emerging role of E2F-1 in the DNA damage response and checkpoint control. | journal = DNA Repair (Amst.) | volume = 3 | issue = 8-9 | pages = 1071–9 | year = 2005 | pmid = 15279795 | doi = 10.1016/j.dnarep.2004.03.034 }}
  • {{cite journal | vauthors = Zhang Z, Wang H, Li M, Rayburn E, Agrawal S, Zhang R | title = Novel MDM2 p53-independent functions identified through RNA silencing technologies. | journal = Ann. N. Y. Acad. Sci. | volume = 1058 | issue = 1 | pages = 205–14 | year = 2006 | pmid = 16394138 | doi = 10.1196/annals.1359.030 }}
  • {{cite journal | vauthors = Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G | title = PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells | journal = Mol. Carcinog. | volume = 48 | issue = 12 | pages = 1149–58 | date = July 2009 | pmid = 19603422 | doi = 10.1002/mc.20569 }}
{{Refend}}

External links

  • {{MeshName|E2F1+protein,+human}}
  • {{FactorBook|E2F1}}
{{PDB Gallery|geneid=1869}}{{Transcription factors|g3}}{{NLM content}}{{DEFAULTSORT:E2f1}}

1 : Transcription factors
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