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词条 E2F2
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]

Interactions

E2F2 has been shown to interact with:

  • BRD2,[4][5]
  • RYBP,[6] and
  • RB1.[7]

See also

  • E2F
{{Clear}}

References

1. ^{{cite journal | vauthors = Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC | title = Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7802–12 | date = January 1994 | pmid = 8246995 | pmc = 364852 | doi = 10.1128/MCB.13.12.7802}}
2. ^{{cite journal | vauthors = Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K | title = The retinoblastoma protein binds to a family of E2F transcription factors | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7813–25 | date = January 1994 | pmid = 8246996 | pmc = 364853 | doi = 10.1128/mcb.13.12.7813}}
3. ^{{cite web | title = Entrez Gene: E2F2 E2F transcription factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1870| accessdate = }}
4. ^{{cite journal | vauthors = Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ | title = Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein | journal = Mol. Endocrinol. | volume = 16 | issue = 8 | pages = 1727–37 | date = August 2002 | pmid = 12145330 | doi = 10.1210/me.2001-0353 }}
5. ^{{cite journal | vauthors = Denis GV, Vaziri C, Guo N, Faller DV | title = RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F | journal = Cell Growth Differ. | volume = 11 | issue = 8 | pages = 417–24 | date = August 2000 | pmid = 10965846 | pmc = 3968681 | doi = }}
6. ^{{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = EMBO J. | volume = 21 | issue = 21 | pages = 5775–86 | date = November 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577}}
7. ^{{cite journal | vauthors = Lee C, Chang JH, Lee HS, Cho Y | title = Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor | journal = Genes Dev. | volume = 16 | issue = 24 | pages = 3199–212 | date = December 2002 | pmid = 12502741 | pmc = 187509 | doi = 10.1101/gad.1046102 }}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors = Dyson N | title = The regulation of E2F by pRB-family proteins. | journal = Genes Dev. | volume = 12 | issue = 15 | pages = 2245–62 | year = 1998 | pmid = 9694791 | doi = 10.1101/gad.12.15.2245 }}
  • {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2536–46 | year = 1995 | pmid = 7739537 | pmc = 230484 | doi = 10.1128/mcb.15.5.2536}}
  • {{cite journal | vauthors = Karlseder J, Rotheneder H, Wintersberger E | title = Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1659–67 | year = 1996 | pmid = 8657141 | pmc = 231152 | doi = 10.1128/mcb.16.4.1659}}
  • {{cite journal | vauthors = Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC | title = Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1668–75 | year = 1996 | pmid = 8657142 | pmc = 231153 | doi = 10.1128/MCB.16.4.1668}}
  • {{cite journal | vauthors = Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM | title = DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 15 | pages = 7594–9 | year = 1996 | pmid = 8755520 | pmc = 38791 | doi = 10.1073/pnas.93.15.7594 }}
  • {{cite journal | vauthors = Magae J, Wu CL, Illenye S, Harlow E, Heintz NH | title = Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members | journal = J. Cell Sci. | volume = 109 | issue = 7 | pages = 1717–26 | year = 1997 | pmid = 8832394 | doi = }}
  • {{cite journal | vauthors = Hofmann F, Livingston DM | title = Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit | journal = Genes Dev. | volume = 10 | issue = 7 | pages = 851–61 | year = 1996 | pmid = 8846921 | doi = 10.1101/gad.10.7.851 }}
  • {{cite journal | vauthors = Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D | title = The subcellular localization of E2F-4 is cell-cycle dependent | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 10 | pages = 5095–100 | year = 1997 | pmid = 9144196 | pmc = 24637 | doi = 10.1073/pnas.94.10.5095 }}
  • {{cite journal | vauthors = Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG | title = Differential activities of E2F family members: unique functions in regulating transcription | journal = Mol. Carcinog. | volume = 22 | issue = 3 | pages = 190–8 | year = 1998 | pmid = 9688145 | doi = 10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P }}
  • {{cite journal | vauthors = Halaban R, Cheng E, Smicun Y, Germino J | title = Deregulated E2F transcriptional activity in autonomously growing melanoma cells | journal = J. Exp. Med. | volume = 191 | issue = 6 | pages = 1005–16 | year = 2000 | pmid = 10727462 | pmc = 2193116 | doi = 10.1084/jem.191.6.1005 }}
  • {{cite journal | vauthors = Takahashi Y, Rayman JB, Dynlacht BD | title = Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression | journal = Genes Dev. | volume = 14 | issue = 7 | pages = 804–16 | year = 2000 | pmid = 10766737 | pmc = 316494 | doi = 10.1101/gad.14.7.804| doi-broken-date = 2019-02-21 }}
  • {{cite journal | vauthors = Denis GV, Vaziri C, Guo N, Faller DV | title = RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F | journal = Cell Growth Differ. | volume = 11 | issue = 8 | pages = 417–24 | year = 2001 | pmid = 10965846 | doi = | pmc=3968681}}
  • {{cite journal | vauthors = Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G | title = The E2F1-3 transcription factors are essential for cellular proliferation | journal = Nature | volume = 414 | issue = 6862 | pages = 457–62 | year = 2001 | pmid = 11719808 | doi = 10.1038/35106593 }}
  • {{cite journal | vauthors = Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M | title = ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) | journal = Eur. J. Biochem. | volume = 268 | issue = 23 | pages = 6076–82 | year = 2002 | pmid = 11733001 | doi = 10.1046/j.0014-2956.2001.02555.x }}
  • {{cite journal | vauthors = Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ | title = Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis | journal = Genes Dev. | volume = 16 | issue = 2 | pages = 235–44 | year = 2002 | pmid = 11799066 | pmc = 155318 | doi = 10.1101/gad.943102 }}
  • {{cite journal | vauthors = Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ | title = Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein | journal = Mol. Endocrinol. | volume = 16 | issue = 8 | pages = 1727–37 | year = 2003 | pmid = 12145330 | doi = 10.1210/me.2001-0353 }}
  • {{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = EMBO J. | volume = 21 | issue = 21 | pages = 5775–86 | year = 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}
{{refend}}

External links

  • {{MeshName|E2F2+protein,+human}}
{{Transcription factors|g3}}{{NLM content}}{{gene-1-stub}}

1 : Transcription factors
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