E46 may refer to:

• BMW 3 Series (E46)
• European route E46
• Kamaishi Expressway and Akita Expressway (between Kitakami JCT and Kawabe JCT), route E46 in Japan

• Luis
• Luis Abel Xavier
• Luisa Capetillo
• Luisa Carvajal y Mendoza
• Luisa Casati
• Luisa Cáceres de Arismendi
• Luisa de Carvajal
• Luisa de Carvajal y Mendoza
• Luisa Durán
• Luisa Fernanda
• Luisa Fernanda Rudi
• Luisa Fernanda Rudi Ubeda
• Luis A. Ferre
• Luis A. Ferré
• Luis A. Ferré Performing Arts Center
• Luis Agote
• Luis Alberto Lacalle
• Luis Alberto Monge
• Luis Alberto Moreno
• Luis Alberto Perez
• Luis Alberto Pérez-Rionda
• Luis Alberto Riart
• Luis Alberto Spinetta
• Luis Alberto Villalta
• Luis Alfredo Palacio