Eastcombe may refer to:

• Eastcombe, Gloucestershire, England
• Eastcombe, Mendip, Somerset, England
• Eastcombe, Taunton Deane, Somerset, England

• 4-PO-DMT
• 4-point play
• 4-poster
• 4-power treaty
• 4 power treaty
• 4-Pyranone
• 4-pyranone
• 4-pyridinamine
• 4-pyridinecarboxylic acid
• 4-pyridoxolactonase
• 4-pyridylamine
• 4-Pyrone
• 4-pyrone
• 4Q
• 4Q240
• 4Q246
• 4Q246 (Aramaic Apocalypse)
• 4Q252
• 4Q417
• 4Q448
• 4QA
• 4QAA
• 4QB
• 4QBB
• 4QCantb