“EBAG9”的意思、由来-开放百科全书

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.^[1]

References

1. ^{{cite web | title = Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9166| accessdate = }}

Further reading

{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}

{{cite journal | author=Watanabe T |title=Isolation of Estrogen-Responsive Genes with a CpG Island Library |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 442–9 |year= 1998 |pmid= 9418891 |doi= 10.1128/mcb.18.1.442| pmc=121513 |name-list-format=vanc| author2=Inoue S | author3=Hiroi H | display-authors=3 | last4=Orimo | first4=A | last5=Kawashima | first5=H | last6=Muramatsu | first6=M }}

{{cite journal | vauthors=Nakashima M, Sonoda K, Watanabe T |title=Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1 |journal=Nat. Med. |volume=5 |issue= 8 |pages= 938–42 |year= 1999 |pmid= 10426319 |doi= 10.1038/11383 }}

{{cite journal | author=Ikeda K |title=Promoter analysis and chromosomal mapping of human EBAG9 gene |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 654–60 |year= 2000 |pmid= 10873660 |doi= 10.1006/bbrc.2000.2920 |name-list-format=vanc| author2=Sato M | author3=Tsutsumi O | display-authors=3 | last4=Tsuchiya | first4=Fujiko | last5=Tsuneizumi | first5=Michiko | last6=Emi | first6=Mitsuru | last7=Imoto | first7=Issei | last8=Inazawa | first8=Johji | last9=Muramatsu | first9=Masami }}

{{cite journal | author=Ohshima K |title=Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege |journal=Clin. Exp. Immunol. |volume=123 |issue= 3 |pages= 481–6 |year= 2001 |pmid= 11298137 |doi=10.1046/j.1365-2249.2001.01461.x | pmc=1906005 |name-list-format=vanc| author2=Nakashima M | author3=Sonoda K | display-authors=3 | last4=Kikuchi | first4=M. | last5=Watanabe | first5=T. }}

{{cite journal | author=Matsushima T |title=Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells |journal=Blood |volume=98 |issue= 2 |pages= 313–21 |year= 2001 |pmid= 11435298 |doi=10.1182/blood.V98.2.313 |name-list-format=vanc| author2=Nakashima M | author3=Oshima K | display-authors=3 | last4=Abe | first4=Y | last5=Nishimura | first5=J | last6=Nawata | first6=H | last7=Watanabe | first7=T | last8=Muta | first8=K }}

{{cite journal | author=Tsuneizumi M |title=Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers |journal=Clin. Cancer Res. |volume=7 |issue= 11 |pages= 3526–32 |year= 2002 |pmid= 11705872 |doi= |name-list-format=vanc| author2=Emi M | author3=Nagai H | display-authors=3 | last4=Harada | first4=H | last5=Sakamoto | first5=G | last6=Kasumi | first6=F | last7=Inoue | first7=S | last8=Kazui | first8=T | last9=Nakamura | first9=Y }}

{{cite journal | author=Umeoka K |title=Immunohistochemical analysis of RCAS1 in human pituitary adenomas |journal=Mod. Pathol. |volume=14 |issue= 12 |pages= 1232–6 |year= 2002 |pmid= 11743045 |doi= 10.1038/modpathol.3880467 |name-list-format=vanc| author2=Sanno N | author3=Oyama K | display-authors=3 | last4=Tahara | first4=Shigeyuki | last5=Kurotani | first5=Reiko | last6=Ikuyama | first6=Shoichiro | last7=Nakashima | first7=Manabu | last8=Watanabe | first8=Takeshi | last9=Osamura | first9=R. Yoshiyuki }}

{{cite journal | author=Hiraoka K |title=High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker |journal=Int. J. Cancer |volume=99 |issue= 3 |pages= 418–23 |year= 2002 |pmid= 11992411 |doi= 10.1002/ijc.10381 |name-list-format=vanc| author2=Hida Y | author3=Miyamoto M | display-authors=3 | last4=Oshikiri | first4=Taro | last5=Suzuoki | first5=Masato | last6=Nakakubo | first6=Yoshihiro | last7=Shinohara | first7=Toshiya | last8=Itoh | first8=Tomoo | last9=Shichinohe | first9=Toshiaki }}

{{cite journal | author=Rousseau J |title=RCAS1 is associated with ductal breast cancer progression |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 5 |pages= 1544–9 |year= 2002 |pmid= 12054692 |doi= 10.1016/S0006-291X(02)00401-1 |name-list-format=vanc| author2=Têtu B | author3=Caron D | display-authors=3 | last4=Malenfant | first4=Patrick | last5=Cattaruzzi | first5=Paola | last6=Audette | first6=Marie | last7=Doillon | first7=Charles | last8=Tremblay | first8=Jacques P | last9=Guérette | first9=Benoit }}

{{cite journal | author=Oizumi S |title=RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung |journal=Oncology |volume=62 |issue= 4 |pages= 333–9 |year= 2002 |pmid= 12138241 |doi=10.1159/000065065 |name-list-format=vanc| author2=Yamazaki K | author3=Nakashima M | display-authors=3 | last4=Watanabe | first4=Takeshi | last5=Hommura | first5=Fumihiro | last6=Ogura | first6=Shigeaki | last7=Nishimura | first7=Masaharu | last8=Dosaka-Akita | first8=Hirotoshi }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Engelsberg A |title=The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22998–3007 |year= 2003 |pmid= 12672804 |doi= 10.1074/jbc.M301361200 |name-list-format=vanc| author2=Hermosilla R | author3=Karsten U | display-authors=3 | last4=Schülein | first4=R | last5=Dörken | first5=B | last6=Rehm | first6=A }}

{{cite journal | author=Abe Y |title=Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis |journal=Int. J. Hematol. |volume=77 |issue= 4 |pages= 359–63 |year= 2003 |pmid= 12774924 |doi=10.1007/BF02982644 |name-list-format=vanc| author2=Ohshima K | author3=Nakashima M | display-authors=3 | last4=Hara | first4=Keiichi | last5=Matsushima | first5=Takamitsu | last6=Choi | first6=Ilseung | last7=Nishimura | first7=Junji | last8=Kikuch | first8=Masahiro | last9=Nawata | first9=Hajime }}

{{cite journal | author=Takahashi S |title=EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer |journal=Int. J. Cancer |volume=106 |issue= 3 |pages= 310–5 |year= 2003 |pmid= 12845666 |doi= 10.1002/ijc.11205 |name-list-format=vanc| author2=Urano T | author3=Tsuchiya F | display-authors=3 | last4=Fujimura | first4=Tetsuya | last5=Kitamura | first5=Tadaichi | last6=Ouchi | first6=Yasuyoshi | last7=Muramatsu | first7=Masami | last8=Inoue | first8=Satoshi }}

{{cite journal | author=Sonoda K |title=Association between RCAS1 expression and clinical outcome in uterine endometrial cancer |journal=Br. J. Cancer |volume=89 |issue= 3 |pages= 546–51 |year= 2003 |pmid= 12888828 |doi= 10.1038/sj.bjc.6601126 | pmc=2394364 |name-list-format=vanc| author2=Miyamoto S | author3=Hirakawa T | display-authors=3 | last4=Kaku | first4=T | last5=Nakashima | first5=M | last6=Watanabe | first6=T | last7=Akazawa | first7=K | last8=Fujita | first8=T | last9=Nakano | first9=H }}

{{cite journal | author=Leelawat K |title=Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer |journal=J. Clin. Pathol. |volume=56 |issue= 10 |pages= 764–8 |year= 2003 |pmid= 14514780 |doi=10.1136/jcp.56.10.764 | pmc=1770069 |name-list-format=vanc| author2=Watanabe T | author3=Nakajima M | display-authors=3 | last4=Tujinda | first4=S | last5=Suthipintawong | first5=C | last6=Leardkamolkarn | first6=V }}

{{cite journal | author=Ikeguchi M |title=Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma |journal=Oncol. Rep. |volume=10 |issue= 6 |pages= 1891–4 |year= 2004 |pmid= 14534714 |doi= 10.3892/or.10.6.1891|name-list-format=vanc| author2=Ohoro S | author3=Maeda Y | display-authors=3 | last4=Yamaguchi | first4=K | last5=Fukuda | first5=K | last6=Shirai | first6=H | last7=Kondo | first7=A | last8=Tsujitani | first8=S | last9=Kaibara | first9=N }}

{{cite journal | vauthors=Ikeguchi M, Hirooka Y, Kaibara N |title=Gene and protein expression of RCAS1 in hepatocellular carcinoma |journal=Anticancer Res. |volume=23 |issue= 6D |pages= 4967–71 |year= 2004 |pmid= 14981953 |doi= }}

{{cite journal | author=Brill LM |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |name-list-format=vanc| author2=Salomon AR | author3=Ficarro SB | display-authors=3 | last4=Mukherji | first4=Mridul | last5=Stettler-Gill | first5=Michelle | last6=Peters | first6=Eric C. }}