| 词条 | EMR1 |
| 释义 |
}}{{Infobox gene}}EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.[1][2][3][4][5] EMR1 is a member of the adhesion GPCR family.[6][7] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[8] EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells.[9] The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.[10] The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.[11] FunctionUtilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.[12] Clinical significanceLegrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.[13] See also
References1. ^{{cite journal | vauthors = Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M | title = EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments | journal = Genomics | volume = 26 | issue = 2 | pages = 334–44 | date = March 1995 | pmid = 7601460 | pmc = | doi = 10.1016/0888-7543(95)80218-B }} 2. ^{{cite journal | vauthors = McKnight AJ, Gordon S | title = The EGF-TM7 family: unusual structures at the leukocyte surface | journal = Journal of Leukocyte Biology | volume = 63 | issue = 3 | pages = 271–80 | date = March 1998 | pmid = 9500513 | pmc = | doi = 10.1002/jlb.63.3.271}} 3. ^{{cite web | title = Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015| accessdate = }} 4. ^{{cite journal | vauthors = Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W | title = Markers of mouse macrophage development detected by monoclonal antibodies | journal = Journal of Immunological Methods | volume = 174 | issue = 1–2 | pages = 5–19 | date = September 1994 | pmid = 8083537 | doi = 10.1016/0022-1759(94)90005-1 }} 5. ^{{cite journal|last1=Hamann|first1=J|last2=Aust|first2=G|last3=Araç|first3=D|last4=Engel|first4=FB|last5=Formstone|first5=C|last6=Fredriksson|first6=R|last7=Hall|first7=RA|last8=Harty|first8=BL|last9=Kirchhoff|first9=C|last10=Knapp|first10=B|last11=Krishnan|first11=A|last12=Liebscher|first12=I|last13=Lin|first13=HH|last14=Martinelli|first14=DC|last15=Monk|first15=KR|last16=Peeters|first16=MC|last17=Piao|first17=X|last18=Prömel|first18=S|last19=Schöneberg|first19=T|last20=Schwartz|first20=TW|last21=Singer|first21=K|last22=Stacey|first22=M|last23=Ushkaryov|first23=YA|last24=Vallon|first24=M|last25=Wolfrum|first25=U|last26=Wright|first26=MW|last27=Xu|first27=L|last28=Langenhan|first28=T|last29=Schiöth|first29=HB|title=International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.|journal=Pharmacological Reviews|date=April 2015|volume=67|issue=2|pages=338–67|pmid=25713288|doi=10.1124/pr.114.009647|pmc=4394687}} 6. ^{{cite book | author = Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 978-1-4419-7912-4 }} 7. ^{{cite journal|last1=Langenhan|first1=T|last2=Aust|first2=G|last3=Hamann|first3=J|title=Sticky signaling--adhesion class G protein-coupled receptors take the stage.|journal=Science Signaling|date=21 May 2013|volume=6|issue=276|pages=re3|pmid=23695165|doi=10.1126/scisignal.2003825}} 8. ^{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–78 | date = March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }} 9. ^{{cite journal | vauthors = Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, Lin HH, Gordon S, Kwakkenbos MJ | title = EMR1, the human homolog of F4/80, is an eosinophil-specific receptor | journal = European Journal of Immunology | volume = 37 | issue = 10 | pages = 2797–802 | date = October 2007 | pmid = 17823986 | doi = 10.1002/eji.200737553 }} 10. ^{{cite journal | vauthors = Austyn JM, Gordon S | title = F4/80, a monoclonal antibody directed specifically against the mouse macrophage | journal = European Journal of Immunology | volume = 11 | issue = 10 | pages = 805–15 | date = October 1981 | pmid = 7308288 | doi = 10.1002/eji.1830111013 }} 11. ^{{cite journal | vauthors = Gordon S, Hamann J, Lin HH, Stacey M | title = F4/80 and the related adhesion-GPCRs | journal = European Journal of Immunology | volume = 41 | issue = 9 | pages = 2472–6 | date = September 2011 | pmid = 21952799 | doi = 10.1002/eji.201141715 }} 12. ^{{cite journal | vauthors = Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J | title = The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance | journal = The Journal of Experimental Medicine | volume = 201 | issue = 10 | pages = 1615–25 | date = May 2005 | pmid = 15883173 | doi = 10.1084/jem.20042307 | pmc=2212925}} 13. ^{{cite journal | vauthors = Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, Makiya MA, Palath V, Leung J, Baer M, Yarranton G, Maric I, Bebbington C, Klion AD | title = The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders | journal = The Journal of Allergy and Clinical Immunology | volume = 133 | issue = 5 | pages = 1439–47, 1447.e1–8 | date = May 2014 | pmid = 24530099 | doi = 10.1016/j.jaci.2013.11.041 | pmc=4113341}} External links
1 : G protein-coupled receptors |
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