| 词条 | Enhanceosome |
| 释义 |
The enhanceosome is a higher-order protein complex assembled at the enhancer and regulates expression of a target gene.[1] The binding and assembly of the activating proteins is cooperative due to energetically favorable protein-protein interactions formed in the complex. The best known example of the enhanceosome acts on the human interferon-beta gene, which is upregulated in cells that are infected by viruses.[2] Three activator proteins—NF-κB, an interferon activator protein such as IRF-3, and the ATF-2/c-Jun complex—cooperatively bind to the upstream enhancer region upon viral infection. The interaction is mediated by a fourth protein HMG-I, which assists in stabilizing the complex by promoting inter-protein interactions. The assembled enhanceosome recruits transcriptional machinery such as RNA polymerase to the promoter region to initiate gene expression.[1][2] References1. ^1 {{cite journal |last=Merika |first=M |author2=Thanos, D |title=Enhanceosomes |journal=Current Opinion in Genetics & Development|date=April 2001 |volume=11 |issue=2 |pages=205–8 |pmid=11250145 |doi=10.1016/s0959-437x(00)00180-5}} 2. ^1 {{cite journal |last=Panne |first=D |title=The enhanceosome |journal=Current Opinion in Structural Biology |date=April 2008 |volume=18 |issue=2 |pages=236–42 |pmid=18206362 |doi=10.1016/j.sbi.2007.12.002}} External links
1 : Genetics |
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