| 词条 | Enoximone |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443725104 | IUPAC_name = 4-Methyl-5[4-(methylsulfanyl)phenyl]carbonyl2,3-dihydro-1H-imidazol-2-one | image = Enoximone.svg | tradename = Perfan | Drugs.com = {{drugs.com|international|enoximone}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_UK = POM | legal_US = | legal_status = | routes_of_administration = Intravenous | bioavailability = 50% (oral) | protein_bound = 85% | metabolism = Liver (oxidation) | elimination_half-life = 4 to 10 hours | excretion = Renal (60 to 70%) | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 77671-31-9 | ATC_prefix = C01 | ATC_suffix = CE03 | PubChem = 53708 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB04880 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 48492 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = C7Z4ITI7L7 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D04004 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 249856 | C=12 | H=12 | N=2 | O=2 | S=1 | molecular_weight = 248.302 g/mol | smiles = O=C(/C1=C(/NC(=O)N1)C)c2ccc(SC)cc2 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZJKNESGOIKRXQY-UHFFFAOYSA-N | melting_point = 255 | melting_high = 258 | melting_notes = (decomposes) }}Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.[1] Synthesis[2]Prepn: {{Cite patent|BE|883856}} (1980 to Richardson-Merrell); R. A. Schnettler et al., {{US patent|4405635}} (1983 to Merrell-Dow) References1. ^{{cite journal |vauthors=Boldt J, Suttner S |title=Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone |journal=Expert Opin Pharmacother |volume=8 |issue=13 |pages=2135–47 |date=September 2007 |pmid=17714066 |doi=10.1517/14656566.8.13.2135 |url=}} {{Phosphodiesterase inhibitors}}{{Cardiac stimulants excluding cardiac glycosides}}{{cardiovascular-drug-stub}}2. ^{{cite journal|last1=Schnettler|first1=Richard A.|last2=Dage|first2=Richard C.|last3=Grisar|first3=J. Martin|title=4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents|journal=Journal of Medicinal Chemistry|volume=25|issue=12|year=1982|pages=1477–1481|issn=0022-2623|doi=10.1021/jm00354a017}} 8 : Cardiac stimulants|Imidazolines|Inotropic agents|Ketones|Lactams|PDE3 inhibitors|Thioethers|Ureas |
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