| 词条 | Epimerase and racemase |
| 释义 |
Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry. Epimerases catalyze the stereochemical inversion of the configuration about an asymmetric carbon atom in a substrate having more than one center of asymmetry, thus interconverting epimers. Human epimerases include methylmalonyl-CoA epimerase, involved in the metabolic breakdown of the amino acids alanine, isoleucine, methionine and valine,[2] and UDP-glucose 4-epimerase, which is used in the final step of galactose metabolism - catalyzing the reversible conversion of UDP-galactose to UDP-glucose. References1. ^{{cite journal | author = Tanner, ME. | title = Understanding nature's strategies for enzyme-catalyzed racemization and epimerization | journal = Acc. Chem. Res. | year=2002 | volume=35 | issue=4 | pages=237–246 | pmid = 11955052 | doi = 10.1021/ar000056y }} 2. ^http://www.britannica.com/science/isomerase External links
1 : Isomerases |
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