| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .[1] Function This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.[2] References 1. ^{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}
2. ^{{cite web | title = Entrez Gene: ESRRB estrogen-related receptor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2103| accessdate = }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Giguère V, Yang N, Segui P, Evans RM | title = Identification of a new class of steroid hormone receptors | journal = Nature | volume = 331 | issue = 6151 | pages = 91–4 | date = Jan 1988 | pmid = 3267207 | doi = 10.1038/331091a0 }}
- {{cite journal | vauthors = Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V | title = Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene | journal = Genomics | volume = 45 | issue = 2 | pages = 320–6 | date = Oct 1997 | pmid = 9344655 | doi = 10.1006/geno.1997.4939 }}
- {{cite journal | vauthors = Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjöld M, Gustafsson JA | title = Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 82 | issue = 12 | pages = 4258–65 | date = Dec 1997 | pmid = 9398750 | doi = 10.1210/jc.82.12.4258 }}
- {{cite journal | vauthors = Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT | title = Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR | journal = Gene | volume = 228 | issue = 1-2 | pages = 101–9 | date = Mar 1999 | pmid = 10072763 | doi = 10.1016/S0378-1119(98)00619-2 }}
- {{cite journal | vauthors = Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM | title = Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2 | journal = Molecular Endocrinology | volume = 13 | issue = 12 | pages = 2151–62 | date = Dec 1999 | pmid = 10598588 | doi = 10.1210/me.13.12.2151 }}
- {{cite journal | vauthors = Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE |authorlink4=Jane Dyson| title = Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition | journal = Journal of Molecular Biology | volume = 327 | issue = 4 | pages = 819–32 | date = Apr 2003 | pmid = 12654265 | doi = 10.1016/S0022-2836(03)00183-9 }}
- {{cite journal | vauthors = Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF | title = Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution | journal = The Journal of Comparative Neurology | volume = 466 | issue = 2 | pages = 251–77 | date = Nov 2003 | pmid = 14528452 | doi = 10.1002/cne.10899 }}
- {{cite journal | vauthors = Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS | title = Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors | journal = Endocrinology | volume = 145 | issue = 7 | pages = 3473–86 | date = Jul 2004 | pmid = 15033914 | doi = 10.1210/en.2003-1682 }}
- {{cite journal | vauthors = Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA | title = Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism | journal = FASEB Journal | volume = 18 | issue = 11 | pages = 1252–4 | date = Aug 2004 | pmid = 15208259 | doi = 10.1096/fj.03-1088fje }}
- {{cite journal | vauthors = Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, Eren M, Vaughan DE | title = Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells | journal = Circulation Research | volume = 95 | issue = 3 | pages = 269–75 | date = Aug 2004 | pmid = 15217907 | doi = 10.1161/01.RES.0000136521.70093.f1 }}
- {{cite journal | vauthors = Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA | title = Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 2 | pages = 1041–6 | date = Feb 2005 | pmid = 15536156 | doi = 10.1210/jc.2004-1211 }}
- {{cite journal | vauthors = Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL | title = Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 3 | pages = 1830–44 | date = Mar 2005 | pmid = 15598686 | doi = 10.1210/jc.2004-1421 }}
- {{cite journal | vauthors = Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB | title = Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 91 | issue = 2 | pages = 569–79 | date = Feb 2006 | pmid = 16332939 | doi = 10.1210/jc.2004-1957 }}
{{refend}}{{NLM content}}{{gene-14-stub}}{{PDB Gallery|geneid=2103}}{{Transcription factors|g2}}{{Nuclear receptor ligands}} 2 : Intracellular receptors|Transcription factors |