| 词条 | Factor VIII (medication) |
| 释义 |
| drug_name = Factor VIII | INN = | type = | IUPAC_name = | image = Fviii 2R7E.png | alt = | caption = A depiction of factor VIII | pronounce = | tradename = Aafact, octocog alfa, others[1] | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = intravenous | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = | class = | ATCvet = | ATC_prefix = B02 | ATC_suffix = BD02 | PubChem = | DrugBank = | ChemSpiderID = none | chemical_formula = | molecular_weight = }}Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII.[2][3] Certain preparations may also be used in those with von Willebrand's disease.[3] It is given by slow injection into a vein.[2] Side effects include skin flushing, shortness of breath, fever, and red blood cell breakdown.[2][3] Allergic reactions including anaphylaxis may occur.[3] It is unclear if use during pregnancy is safe for the baby.[3] A purified factor VIII concentrate is made from human blood plasma.[4] A recombinant version is also available.[2] People may develop antibodies to factor VIII such that this medication becomes less effective.[3] Factor VIII was first identified in the 1940s and became available as a medication in the 1960s.[5][6] Recombinant factor VIII was first made in 1984 and approved for medical use in the United States in 1992.[7][8] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[9] The wholesale cost in the developing world is about US$ 119–497 per 500 iu vial.[10] HistoryThis transfer of a plasma byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV and hepatitis before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy. References1. ^{{cite web|title=Coagulation Factor VIII, Human|url=https://www.drugs.com/international/coagulation-factor-viii-human.html|website=www.drugs.com|accessdate=8 January 2017|deadurl=no|archiveurl=https://web.archive.org/web/20170109023010/https://www.drugs.com/international/coagulation-factor-viii-human.html|archivedate=9 January 2017|df=}} {{portal bar|Pharmacy and pharmacology|Medicine}}{{blood-drug-stub}}2. ^1 2 3 {{cite book|title=WHO Model Formulary 2008|date=2009|publisher=World Health Organization|isbn=978-9241547659|pages=259–260|url=http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|accessdate=8 January 2017|deadurl=no|archiveurl=https://web.archive.org/web/20161213060118/http://apps.who.int/medicinedocs/documents/s16879e/s16879e.pdf|archivedate=13 December 2016|df=}} 3. ^1 {{cite web|title=Alphanate – Summary of Product Characteristics (SPC) – (eMC)|url=https://www.medicines.org.uk/emc/medicine/21167|website=www.medicines.org.uk|accessdate=8 January 2017|deadurl=no|archiveurl=https://web.archive.org/web/20170109021426/https://www.medicines.org.uk/emc/medicine/21167|archivedate=9 January 2017|df=}} 4. ^1 2 3 4 {{cite book|title=British National Formulary : BNF 69|date=2015|publisher=British Medical Association|isbn=978-0857111562|page=171|edition=}} 5. ^{{cite book|last1=Potts|first1=D.M.|title=Queen Victoria's Gene: Haemophilia and the Royal Family (Chapter 5)|publisher=The History Press|year=2011|isbn=978-0752471969|url=https://books.google.ca/books?id=tKwTDQAAQBAJ&pg=PT61|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20170109021311/https://books.google.ca/books?id=tKwTDQAAQBAJ&pg=PT61|archivedate=2017-01-09|df=}} 6. ^{{cite book|last1=Sibinga|first1=Cees Smit|last2=Das|first2=P.C.|last3=Overby|first3=L.R.|title=Biotechnology in blood transfusion: Proceedings of the Twelfth Annual Symposium on Blood Transfusion, Groningen 1987, organized by the Red Cross Blood Bank Groningen-Drenthe|date=2012|publisher=Springer Science & Business Media|isbn=978-1461317616|page=224|url=https://books.google.ca/books?id=z1IlBAAAQBAJ&pg=PA224|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20170109022859/https://books.google.ca/books?id=z1IlBAAAQBAJ&pg=PA224|archivedate=2017-01-09|df=}} 7. ^{{cite book|last1=Buckel|first1=P.|title=Recombinant Protein Drugs|date=2012|publisher=Birkhäuser|isbn=978-3034883467|page=79|url=https://books.google.ca/books?id=cSX3BwAAQBAJ&pg=PA79|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20170109022522/https://books.google.ca/books?id=cSX3BwAAQBAJ&pg=PA79|archivedate=2017-01-09|df=}} 8. ^{{cite book|last1=Hillyer|first1=Christopher D.|title=Blood Banking and Transfusion Medicine: Basic Principles & Practice|publisher=Elsevier Health Sciences|isbn=0443069816|year=2006|page=353|url=https://books.google.ca/books?id=3QwXx_enKbcC&pg=PT374|language=en|deadurl=no|archiveurl=https://web.archive.org/web/20170109022838/https://books.google.ca/books?id=3QwXx_enKbcC&pg=PT374|archivedate=2017-01-09|df=}} 9. ^{{cite web|title=WHO Model List of Essential Medicines (19th List)|url=http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|work=World Health Organization|accessdate=8 December 2016|date=April 2015|deadurl=no|archiveurl=https://web.archive.org/web/20161213052708/http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1|archivedate=13 December 2016|df=}} 10. ^{{cite web|title=Factor Viii|url=http://mshpriceguide.org/en/single-drug-information/?DMFId=911&searchYear=2014|website=International Drug Price Indicator Guide|accessdate=8 December 2016}} 4 : Antihemorrhagics|World Health Organization essential medicines|RTT|Takeda Pharmaceutical Company |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。