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词条 FBLN1
释义

  1. Function

  2. Structure

  3. Interactions

  4. See also

  5. References

  6. Further reading

{{Infobox_gene}}FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.[1][2][3]

Function

Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes. Fibulin-1 binds to a number of extracellular matrix constituents including fibronectin,[3] nidogen-1, and the proteoglycan, versican.[3][4] Fibulin-1 is also a blood protein capable of binding to fibrinogen.[5]

Structure

Fibulin-1 has modular domain structure and includes a series of nine epidermal growth factor-like modules followed by a fibulin-type module, a module found in all members of the fibulin gene family.[2]

The human fibulin-1 gene, FBLN1, encodes four splice variants designated fibulin-1A, B, C and D, which differ in their carboxy terminal regions. In mouse, chicken and the nematode, C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.[1]

Interactions

FBLN1 has been shown to interact with:

{{div col|colwidth=20em}}
  • NOV/CCN3,[6]
  • amyloid precursor protein,[7]
  • entactin,[8][9][10]
  • fibrinogen,[5] and
  • fibronectin.[11]
{{Div col end}}

See also

  • Synpolydactyly

References

1. ^1 {{cite web | title = Entrez Gene: FBLN1 fibulin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2192| accessdate = }}
2. ^1 {{cite journal | vauthors = Argraves WS, Tran H, Burgess WH, Dickerson K | title = Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure | journal = The Journal of Cell Biology | volume = 111 | issue = 6 Pt 2 | pages = 3155–64 | date = Dec 1990 | pmid = 2269669 | pmc = 2116371 | doi = 10.1083/jcb.111.6.3155 }}
3. ^1 2 {{cite journal | vauthors = Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS | title = Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin | journal = The Journal of Biological Chemistry | volume = 267 | issue = 28 | pages = 20120–5 | date = Oct 1992 | pmid = 1400330 | doi = | url = http://www.jbc.org/cgi/content/abstract/267/28/20120 }}
4. ^{{cite journal | vauthors = Timpl R, Sasaki T, Kostka G, Chu ML | title = Fibulins: a versatile family of extracellular matrix proteins | journal = Nature Reviews Molecular Cell Biology | volume = 4 | issue = 6 | pages = 479–89 | date = Jun 2003 | pmid = 12778127 | doi = 10.1038/nrm1130 }}
5. ^1 {{cite journal | vauthors = Argraves WS, Tanaka A, Smith EP, Twal WO, Argraves KM, Fan D, Haudenschild CC | title = Fibulin-1 and fibrinogen in human atherosclerotic lesions | journal = Histochemistry and Cell Biology | volume = 132 | issue = 5 | pages = 559–65 | date = Nov 2009 | pmid = 19693531 | doi = 10.1007/s00418-009-0628-7 }}
6. ^{{cite journal | vauthors = Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B | title = The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 3 | pages = 869–74 | date = Feb 1999 | pmid = 9927660 | pmc = 15317 | doi = 10.1073/pnas.96.3.869}}
7. ^{{cite journal | vauthors = Ohsawa I, Takamura C, Kohsaka S | title = Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function | journal = Journal of Neurochemistry | volume = 76 | issue = 5 | pages = 1411–20 | date = Mar 2001 | pmid = 11238726 | doi = 10.1046/j.1471-4159.2001.00144.x}}
8. ^{{cite journal | vauthors = Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G | title = Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules | journal = Journal of Molecular Biology | volume = 272 | issue = 2 | pages = 226–36 | date = Sep 1997 | pmid = 9299350 | doi = 10.1006/jmbi.1997.1244 }}
9. ^{{cite journal | vauthors = Tran H, VanDusen WJ, Argraves WS | title = The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22600–6 | date = Sep 1997 | pmid = 9278415 | doi = 10.1074/jbc.272.36.22600}}
10. ^{{cite journal | vauthors = Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML | title = Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands | journal = European Journal of Biochemistry / FEBS | volume = 215 | issue = 3 | pages = 733–40 | date = Aug 1993 | pmid = 8354280 | doi = 10.1111/j.1432-1033.1993.tb18086.x}}
11. ^{{cite journal | vauthors = Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE | title = Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells | journal = The Journal of Biological Chemistry | volume = 267 | issue = 28 | pages = 19840–5 | date = Oct 1992 | pmid = 1400300 | doi = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS | title = Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin | journal = The Journal of Biological Chemistry | volume = 267 | issue = 28 | pages = 20120–5 | date = Oct 1992 | pmid = 1400330 | doi = }}
  • {{cite journal | vauthors = Argraves WS, Tran H, Burgess WH, Dickerson K | title = Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure | journal = The Journal of Cell Biology | volume = 111 | issue = 6 Pt 2 | pages = 3155–64 | date = Dec 1990 | pmid = 2269669 | pmc = 2116371 | doi = 10.1083/jcb.111.6.3155 }}
  • {{cite journal | vauthors = Argraves WS, Dickerson K, Burgess WH, Ruoslahti E | title = Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain | journal = Cell | volume = 58 | issue = 4 | pages = 623–9 | date = Aug 1989 | pmid = 2527614 | doi = 10.1016/0092-8674(89)90097-4 }}
  • {{cite journal | vauthors = Sasaki T, Göhring W, Pan TC, Chu ML, Timpl R | title = Binding of mouse and human fibulin-2 to extracellular matrix ligands | journal = Journal of Molecular Biology | volume = 254 | issue = 5 | pages = 892–9 | date = Dec 1995 | pmid = 7500359 | doi = 10.1006/jmbi.1995.0664 }}
  • {{cite journal | vauthors = Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD, Argraves WS | title = The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study | journal = The Journal of Histochemistry and Cytochemistry | volume = 43 | issue = 4 | pages = 401–11 | date = Apr 1995 | pmid = 7534784 | doi = 10.1177/43.4.7534784 }}
  • {{cite journal | vauthors = Tran H, Tanaka A, Litvinovich SV, Medved LV, Haudenschild CC, Argraves WS | title = The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis | journal = The Journal of Biological Chemistry | volume = 270 | issue = 33 | pages = 19458–64 | date = Aug 1995 | pmid = 7642629 | doi = 10.1074/jbc.270.33.19458 }}
  • {{cite journal | vauthors = Mattei MG, Pan TC, Zhang RZ, Timpl R, Chu ML | title = The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15 | journal = Genomics | volume = 22 | issue = 2 | pages = 437–8 | date = Jul 1994 | pmid = 7806231 | doi = 10.1006/geno.1994.1406 }}
  • {{cite journal | vauthors = Korenberg JR, Chen XN, Tran H, Argraves WS | title = Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13.3 | journal = Cytogenetics and Cell Genetics | volume = 68 | issue = 3–4 | pages = 192–3 | year = 1995 | pmid = 7842734 | doi = 10.1159/000133911 }}
  • {{cite journal | vauthors = Brown JC, Wiedemann H, Timpl R | title = Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta | journal = Journal of Cell Science | volume = 107 | issue = 1 | pages = 329–38 | date = Jan 1994 | pmid = 8175920 | doi = }}
  • {{cite journal | vauthors = Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML | title = Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands | journal = European Journal of Biochemistry / FEBS | volume = 215 | issue = 3 | pages = 733–40 | date = Aug 1993 | pmid = 8354280 | doi = 10.1111/j.1432-1033.1993.tb18086.x }}
  • {{cite journal | vauthors = Clinton GM, Rougeot C, Derancourt J, Roger P, Defrenne A, Godyna S, Argraves WS, Rochefort H | title = Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 316–20 | date = Jan 1996 | pmid = 8552629 | pmc = 40229 | doi = 10.1073/pnas.93.1.316 }}
  • {{cite journal | vauthors = Miosge N, Götz W, Sasaki T, Chu ML, Timpl R, Herken R | title = The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo | journal = The Histochemical Journal | volume = 28 | issue = 2 | pages = 109–16 | date = Feb 1996 | pmid = 8737292 | doi = 10.1007/BF02331415 }}
  • {{cite journal | vauthors = Godyna S, Diaz-Ricart M, Argraves WS | title = Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen | journal = Blood | volume = 88 | issue = 7 | pages = 2569–77 | date = Oct 1996 | pmid = 8839849 | doi = }}
  • {{cite journal | vauthors = Tran H, Mattei M, Godyna S, Argraves WS | title = Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family | journal = Matrix Biology | volume = 15 | issue = 7 | pages = 479–93 | date = Mar 1997 | pmid = 9106159 | doi = 10.1016/S0945-053X(97)90021-4 }}
  • {{cite journal | vauthors = Tran H, VanDusen WJ, Argraves WS | title = The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22600–6 | date = Sep 1997 | pmid = 9278415 | doi = 10.1074/jbc.272.36.22600 }}
  • {{cite journal | vauthors = Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G | title = Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules | journal = Journal of Molecular Biology | volume = 272 | issue = 2 | pages = 226–36 | date = Sep 1997 | pmid = 9299350 | doi = 10.1006/jmbi.1997.1244 }}
  • {{cite journal | vauthors = Qing J, Maher VM, Tran H, Argraves WS, Dunstan RW, McCormick JJ | title = Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines | journal = Oncogene | volume = 15 | issue = 18 | pages = 2159–68 | date = Oct 1997 | pmid = 9393974 | doi = 10.1038/sj.onc.1201385 }}
  • {{cite journal | vauthors = Hayashido Y, Lucas A, Rougeot C, Godyna S, Argraves WS, Rochefort H | title = Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin | journal = International Journal of Cancer | volume = 75 | issue = 4 | pages = 654–8 | date = Feb 1998 | pmid = 9466671 | doi = 10.1002/(SICI)1097-0215(19980209)75:4<654::AID-IJC26>3.0.CO;2-7 }}
  • {{cite journal | vauthors = Roger P, Pujol P, Lucas A, Baldet P, Rochefort H | title = Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors | journal = The American Journal of Pathology | volume = 153 | issue = 5 | pages = 1579–88 | date = Nov 1998 | pmid = 9811350 | pmc = 1853396 | doi = 10.1016/S0002-9440(10)65746-X }}
  • {{cite journal | vauthors = Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B | title = The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 3 | pages = 869–74 | date = Feb 1999 | pmid = 9927660 | pmc = 15317 | doi = 10.1073/pnas.96.3.869 }}
{{refend}}{{Calcium-binding proteins}}
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