“Ferredoxin—NAD(+) reductase”的意思、由来-开放百科全书

词条

Ferredoxin—NAD(+) reductase

释义

Structural studies
References

{{enzyme
| Name = Ferredoxin-NAD+ reductase
| EC_number = 1.18.1.3
| CAS_number = 39369-37-4
| IUBMB_EC_number = 1/18/1/3
| GO_code = 0008860
| image =
| width =
| caption =
}}

In enzymology, a ferredoxin–NAD⁺ reductase ({{EC number|1.18.1.3}}) is an enzyme that catalyzes the chemical reaction:

reduced ferredoxin + NAD⁺ oxidized ferredoxin + NADH + H⁺

Thus, the two substrates of this enzyme are reduced ferredoxin and NAD⁺, whereas its 3 products are oxidized ferredoxin, NADH, and H⁺. This enzyme participates in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor.

The systematic name of this enzyme is ferredoxin:NAD⁺ oxidoreductase. There are a variety of names in common use:

ferredoxin–nicotinamide adenine dinucleotide reductase
ferredoxin reductase
NAD⁺-ferredoxin reductase
ferredoxin–NAD⁺ reductase
ferredoxin–linked NAD⁺ reductase
ferredoxin–NAD reductase

When NAD molecule is in its reduced form, the enzyme is referred to as:

NADH-ferredoxin oxidoreductase
reduced nicotinamide adenine dinucleotide-ferredoxin
NADH-ferredoxin reductase
NADH flavodoxin oxidoreductase
NADH₂-ferredoxin oxidoreductase

Other enzymes in the family include:

NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)
NADH-ferredoxin TOL reductase (component of toluene dioxygenase)

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1KRH}}.

References

{{cite journal |vauthors=Jungermann K, Thauer RK, Leimenstoll G, Decker K | year = 1973 | title = Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia | journal = Biochim. Biophys. Acta | volume = 305 | pages = 268–80 | pmid = 4147457 | issue = 2 | doi=10.1016/0005-2728(73)90175-8}}

{{Other oxidoreductases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Ferredoxin-NAD(+) reductase}}{{1.18-enzyme-stub}}

3 : EC 1.18.1|NADH-dependent enzymes|Enzymes of known structure

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