First Daughter may refer to:

• The daughter of the President of the United States of America (a colloquialism)
• First Daughter (Brack), a 1955 painting by John Brack
• First Daughter (1999 film), a television film starring Monica Keena and Mariel Hemingway
• First Daughter (2004 film), a feature film starring Katie Holmes
• The First Daughter (novel), a novel by Ugandan author Goretti Kyomuhendo

• Margaret Beauchamp of Bletso
• Margaret Beaufort
• Margaret Beaufort, Countess of Devon
• Margaret Beaufort, Countess of Stafford
• Margaret Beaufort Middle School
• Margaret beaufort middle school
• Margaret Becker
• Margaret becker
• Margaret Becket
• Margaret Bender
• Margaret Bennett (figure skater)
• Margaret Benson
• Margaret Bentinck, Duchess of Portland
• Margaret Berger
• Margaret Bermingham
• Margaret Beryl Jones
• Margaret Betty Harvie Anderson
• Margaret Biggs
• Margaret Biggs, Author
• Margaret Birch
• Margaret B. Kelly
• Margaret Blackman
• Margaret Blair Young
• Margaret Bloodworth
• Margaret Bobonich