“Flavanone 3-dioxygenase”的意思、由来-开放百科全书

词条

Flavanone 3-dioxygenase

释义

References

{{enzyme
| Name = naringenin 3-dioxygenase
| EC_number = 1.14.11.9
| CAS_number = 75991-43-4
| IUBMB_EC_number = 1/14/11/9
| GO_code = 0045486
| image =
| width =
| caption =
}}

In enzymology, a flavanone 3-dioxygenase ({{EC number|1.14.11.9}}) is an enzyme that catalyzes the chemical reaction

a flavanone + 2-oxoglutarate + O₂ a dihydroflavonol + succinate + CO₂

The 3 substrates of this enzyme are flavanone, 2-oxoglutarate, and O₂, whereas its 3 products are dihydroflavonol, succinate, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom o oxygen into each donor. The systematic name of this enzyme class is flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). Other names in common use include naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3beta-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, and naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating). This enzyme participates in flavonoid biosynthesis. It has 2 cofactors: iron, and Ascorbate.

References

{{cite journal |vauthors=Forkmann G, Heller W, Grisebach H | date = 1980 | title = Anthocyanin biosynthesis in flowers of Matthiola incana flavanone 3- and flavonoid 3'-hydroxylases | journal = Z. Naturforsch. C: Biosci. | volume = 35 | pages = 691–695 }}
{{cite journal |vauthors=Wellmann F, Matern U, Lukacin R | date = 2004 | title = Significance of C-terminal sequence elements for Petunia flavanone 3beta-hydroxylase activity | journal = FEBS Lett. | volume = 561 | pages = 149–54 | pmid = 15013767 | doi = 10.1016/S0014-5793(04)00159-0 | issue = 1-3 }}

5 : EC 1.14.11|Iron enzymes|Ascorbate enzymes|Enzymes of unknown structure|Flavanones metabolism

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