“Fluoroacetaldehyde dehydrogenase”的意思、由来-开放百科全书

词条

Fluoroacetaldehyde dehydrogenase

释义

References

{{enzyme
| Name = Fluoroacetaldehyde dehydrogenase
| EC_number = 1.2.1.69
| CAS_number =
| IUBMB_EC_number = 1/2/1/69
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a fluoroacetaldehyde dehydrogenase ({{EC number|1.2.1.69}}) is an enzyme that catalyzes the chemical reaction

fluoroacetaldehyde + NAD⁺ + H₂O fluoroacetate + NADH + 2 H⁺

The 3 substrates of this enzyme are fluoroacetaldehyde, NAD⁺, and H₂O, whereas its 3 products are fluoroacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is fluoroacetaldehyde:NAD+ oxidoreductase.

References

{{cite journal | vauthors = Murphy CD, Moss SJ, O'Hagan D | date = 2001 | title = Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya | journal = Appl. Environ. Microbiol. | volume = 67 | pages = 4919–21 | pmid = 11571203 | doi = 10.1128/AEM.67.10.4919-4921 | issue = 10 | pmc = 93250 }}
{{cite journal | vauthors = Murphy CD, Schaffrath C, O'Hagan D | date = 2003 | title = Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya | journal = Chemosphere | volume = 52 | pages = 455–61 | pmid = 12738270 | doi = 10.1016/S0045-6535(03)00191-7 | issue = 2 }}

3 : EC 1.2.1|NADH-dependent enzymes|Enzymes of unknown structure

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