| 词条 | Fluproquazone |
| 释义 |
| verifiedrevid = 443906983 | IUPAC_name = 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one | image = Fluproquazone.svg | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | CAS_number = 40507-23-1 | ATC_prefix = none | PubChem = 38503 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 35289 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = U4K85O58HD | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D04229 | C=18 | H=17 | F=1 | N=2 | O=1 | molecular_weight = 296.339 g/mol | smiles = Fc3ccc(C/1=N/C(=O)N(c2cc(ccc\\12)C)C(C)C)cc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H17FN2O/c1-11(2)21-16-10-12(3)4-9-15(16)17(20-18(21)22)13-5-7-14(19)8-6-13/h4-11H,1-3H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = ZWOUXWWGKJBAHQ-UHFFFAOYSA-N }} Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz.[1][2][3][4] It was withdrawn during development due to liver toxicity.[5]{{rp|370}}[6]{{rp|520}} References1. ^Haanaes HR, et al RF 46-790 versus paracetamol: effect on post-operative pain. Int J Clin Pharmacol Ther Toxicol. 1986 Nov;24(11):598-601. {{PMID|3491794}} {{NSAIDs}}{{Prostanoidergics}}{{musculoskeletal-drug-stub}}2. ^Mohing W, Suckert R, Lataste X. Comparative study of fluproquazone in the management of post-operative pain. Arzneimittelforschung. 1981;31(5a):918-20. 3. ^Wheatley D. Analgesic properties of fluproquazone. Rheumatology and Rehabilitation. 1982 May;21(2):98-100. 4. ^Fankhauser S, Laube W, Marti HR, Schultheiss HR, Vogtlin J, von Graffenried B. Antipyretic activity of fluproquazone in man. Arzneimittelforschung. 1981;31(5a):934-5. 5. ^Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. {{ISBN|9780123878175}} 6. ^Hyman J. Zimmerman. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. Lippincott Williams & Wilkins, 1999. {{ISBN|9780781719520}} 7 : Nonsteroidal anti-inflammatory drugs|Analgesics|Quinazolines|Lactams|Fluoroarenes|Abandoned drugs|Isopropyl compounds |
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