词条 | FMS-like tyrosine kinase 3 ligand |
释义 |
FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development.[1][2] A lack of FLT3L results in low levels of dendritic cells. FLT3L in parasite clearanceFLT3L and its receptor are involved in the mammalian immune response to malaria. In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to the activation of CD8+ T cells. The same paper suggested that FLT3L release was caused by stimulation of mast cells with uric acid, produced from a precursor secreted by the plasmodium parasite. .[3] References1. ^1 {{cite journal |last1=Shortman |first1=Ken |last2=Naik |first2=Shalin H. |title=Steady-state and inflammatory dendritic-cell development |journal=Nature Reviews Immunology |volume=7 |issue=1 |pages=19–30 |year=2006 |pmid=17170756 |doi=10.1038/nri1996}} 2. ^{{cite journal |last1=Rahman |first1=Adeeb H. |last2=Aloman |first2=Costica |title=Dendritic cells and liver fibrosis |journal=Biochimica et Biophysica Acta |volume=1832 |issue=7 |pages=998–1004 |year=2013 |pmid=23313573 |doi=10.1016/j.bbadis.2013.01.005 |pmc=3641166}} 3. ^{{cite journal |last1=Guermonprez |first1=Pierre |last2=Helft |first2=Julie |title=Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection |journal=Nature Medicine |volume=19 |issue=1 |pages=730–738 |year=2013 |doi=10.1038/nm.3197 |pmid=23685841 |pmc=3914008}} Further reading
External links
2 : Cytokines|Growth factors |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。