“Galactose 1-dehydrogenase (NADP+)”的意思、由来-开放百科全书

词条

Galactose 1-dehydrogenase (NADP+)

释义

References

{{DISPLAYTITLE:Galactose 1-dehydrogenase (NADP⁺)}}{{enzyme
| Name = galactose 1-dehydrogenase (NADP⁺)
| EC_number = 1.1.1.120
| CAS_number = 37250-51-4
| IUBMB_EC_number = 1/1/1/120
| GO_code = 0047910
| image =
| width =
| caption =
}}

In enzymology, a galactose 1-dehydrogenase (NADP⁺) ({{EC number|1.1.1.120}}) is an enzyme that catalyzes the chemical reaction

D-galactose + NADP⁺ D-galactonolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are D-galactose and NADP⁺, whereas its 3 products are D-galactonolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-galactose:NADP⁺ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP⁺), and galactose 1-dehydrogenase (NADP⁺). This enzyme participates in galactose metabolism.

References

{{cite journal |vauthors=Cline AL, Hu AS | date = 1965 | title = The isolation of three sugar dehydrogenases from a {{sic|psuedomonad}} | journal = J. Biol. Chem. | volume = 240 | pages = 4488–92 | pmid = 5845847 | issue = 11 }}
{{cite journal |vauthors=Cline AL, Hu AS | date = 1965 | title = Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad | journal = J. Biol. Chem. | volume = 240 | pages = 4493–7 | pmid = 5845848 | issue = 11 }}
{{cite journal |vauthors=Cline AL, Hu AS | date = 1965 | title = Some physical properties of three sugar dehydrogenases from a pseudomonad | journal = J. Biol. Chem. | volume = 240 | pages = 4498–502 | pmid = 5845849 | issue = 11 }}
{{cite journal |vauthors=Schiwara HW, Domagk GF | date = 1968 | title = Über den Abbau der Desoxyzucker durch Bakterienenzyme, V. Anreicherung und Charakterisierung einer NADP-abhängigen Abequosedehydrogenase aus Pseudomonas putida | trans-title=Degradation of deoxysurgars by bacterial enzymes. V. Purification and characterization of an NADP-dependent abequose dehydrogenase from Pseudomonas putida | language=German | journal = Hoppe-Seyler's Z. Physiol. Chem. | volume = 349 | pages = 1321–9 | pmid = 4387016 | issue = 10 | doi=10.1515/bchm2.1968.349.2.1321}}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of unknown structure

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