| 词条 | Gammaretrovirus core encapsidation signal |
| 释义 |
| Name = Gammaretrovirus core encapsidation signal | image = RF00374.jpg | width = | caption = Predicted secondary structure and sequence conservation of Gammaretro_CES | Symbol = Gammaretro_CES | AltSymbols = | Rfam = RF00374 | miRBase = | miRBase_family = | RNA_type = Cis-reg | Tax_domain = Eukaryota; Viruses | GO = | SO = {{SO|0000233}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The Gammaretrovirus core encapsidation signal is an RNA element known to be essential for stable dimerisation and efficient genome packaging during virus assembly.[1] Dimerisation of the viral RNA genomes is proposed to act as an RNA conformational switch which exposes conserved UCUG elements and enables efficient genome encapsidation.[2] The structure of this element is composed of three stem-loops. Two of the stem-loops called SL-C and SL-D form a single co-axial extend helix. See also
References1. ^1 {{cite journal |vauthors=D'Souza V, Dey A, Habib D, Summers MF |title=NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus |journal=J Mol Biol |volume=337 |issue=2 |pages=427–442 |year=2004 |pmid=15003457 |doi=10.1016/j.jmb.2004.01.037}} 2. ^1 {{cite journal |vauthors=D'Souza V, Summers MF |title=Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus |journal=Nature |volume=431 |issue=7008 |pages=586–590 |year=2004 |pmid=15457265 |doi=10.1038/nature02944}} External links
1 : Cis-regulatory RNA elements |
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