| 词条 | Ganglioneuroma |
| 释义 |
| name = Ganglioneuroma | image = Ganglioneuroma CT scan.jpg | caption = CT scan of a large ganglioneuroma within the chest cavity | | pronounce = | field = | synonyms = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Ganglioneuroma is a rare and benign tumor of the autonomic nerve fibers arising from neural crest sympathogonia, which are completely undifferentiated cells of the sympathetic nervous system.[1] However, ganglioneuromas themselves are fully differentiated neuronal tumors that do not contain immature elements.[2] Ganglioneuromas most frequently occur in the abdomen, however these tumors can grow anywhere sympathetic nervous tissue is found. Other common locations include the adrenal gland, paraspinal retroperitoneum, posterior mediastinum, head, and neck.[1] SymptomsA ganglioneuroma is typically asymptomatic, and is typically only discovered when being examined or treated for another condition. Any symptoms will depend upon the tumor's location and the nearby organs affected. For example, a tumor in the chest area may cause breathing difficulty, chest pain, and trachea compression. If the tumor is located lower in the abdomen, it may cause abdominal pain and bloating. A tumor near the spinal cord may cause spinal deformity or spinal compression, leading to pain and loss of muscle control or sensation in the legs and/or arms.[3] These tumors may produce certain hormones, which can cause diarrhea, an enlarged clitoris (in females), high blood pressure, increased body hair, and sweating.[3] CauseThere are no known risk factors for ganglioneuromas. However, the tumors may be associated with some genetic problems, such as neurofibromatosis type 1.[3] PathologyPathologically, ganglioneuromas are composed of ganglion cells, Schwann cells and fibrous tissue.[4] Ganglioneuromas are solid, firm tumours that typically are white when seen with the naked eye. DiagnosisGanglioneuromas can be diagnosed visually by a CT scan, MRI scan, or an ultrasound of the head, abdomen, or pelvis. Blood and urine tests may be done to determine if the tumor is secreting hormones or other circulating chemicals. A biopsy of the tumor may be required to confirm the diagnosis.[3] TreatmentBecause ganglioneuromas are benign, treatment may not be necessary, as it would expose patients to more risk than leaving it alone. If there are symptoms or major physical deformity, treatment usually consists of surgery to remove the tumor. PrognosisMost ganglioneuromas are noncancerous, thus expected outcome is usually good. However, a ganglioneuroma may become cancerous and spread to other areas, or it may regrow after removal. If the tumor has been present for a long time and has pressed on the spinal cord or caused other symptoms, it may have caused irreversible damage that cannot be corrected with the surgical removal of the tumor. Compression of the spinal cord may result in paralysis, especially if the cause is not detected promptly.[3] Neuroblastic tumorsIt is contained within the neuroblastic tumors group, which includes:[5]
References1. ^1 {{cite web | url = http://emedicine.medscape.com/article/340723-overview | last1 = Jedynak | first1 = Andrzej | editor = L Gill Naul | title = Imaging in Ganglioneuroma and Ganglioneuroblastoma | website = Medscape | publisher = WedbMD | accessdate = 6 February 2014}} 2. ^{{Cite journal | last1 = Shin | first1 = JH. | last2 = Lee | first2 = HK. | last3 = Khang | first3 = SK. | last4 = Kim | first4 = DW. | last5 = Jeong | first5 = AK. | last6 = Ahn | first6 = KJ. | last7 = Choi | first7 = CG. | last8 = Suh | first8 = DC. | title = Neuronal tumors of the central nervous system: radiologic findings and pathologic correlation. | journal = Radiographics | volume = 22 | issue = 5 | pages = 1177–89 |year = | doi = 10.1148/radiographics.22.5.g02se051177 | PMID = 12235346 }} 3. ^1 2 3 4 {{cite web | url = https://www.nlm.nih.gov/medlineplus/ency/article/001437.htm | last1 = Dugdale | first1 = David | last2 = Jasmin | first2 = Luc | title = Ganglioneuroma | website = MedlinePlus | date = 29 August 2012 | publisher = A.D.A.M. Medical Encyclopedia |accessdate = 6 February 2014}} 4. ^{{cite web | url = http://radiopaedia.org/articles/ganglioneuroma | first = Yuranga | last = Weerakkody | title = Ganglioneuroma | website = Radiopaedia.org | publisher = Radiopaedia | accessdate = 6 February 2014}} 5. ^{{cite journal |vauthors=Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B |title=Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee |journal=Cancer |volume=86 |issue=2 |pages=349–63 |date=July 1999 |pmid=10421272 |doi= 10.1002/(sici)1097-0142(19990715)86:2<349::aid-cncr20>3.0.co;2-y|url=}} External links{{Medical resources| DiseasesDB = | ICD10 = {{ICD10|D|36|1}} (ILDS D36.180) | ICD9 = | ICDO = {{ICDO|9490|0}} | OMIM = | MedlinePlus = 001437 | eMedicineSubj = | eMedicineTopic = | MeshID = D005729 }}
2 : Nervous system neoplasia|Dermal and subcutaneous growths |
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