| 词条 | Ganoderic acid |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 428815571 | Name=Ganoderic acid A | ImageFile=Ganoderic acid.png | ImageSize=200px | IUPACName= (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)- | OtherNames= |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=81907-62-2 | PubChem=471002 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 413668 | SMILES = OC(=O)[C@H](C)CC(=O)C[C@@H](C)[C@H]2C[C@H](O)[C@@]1(C)C/3=C(\\C(=O)C[C@@]12C)[C@@]4(C)CCC(=O)[C@](C)(C)[C@@H]4C[C@@H]\\3O | InChI = 1/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1 | InChIKey = DYOKDAQBNHPJFD-JNTBEZBXBK | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = DYOKDAQBNHPJFD-JNTBEZBXSA-N |Section2={{Chembox Properties | Formula=C30H44O7 | MolarMass=516.67 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia.[1] Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection,[2] anti-tumor effects,[4] and 5-alpha reductase inhibition.[5] References1. ^{{cite journal |doi=10.1016/0031-9422(89)85036-8 |title=Bitter triterpenoids from the fungus Ganoderma applanatum |journal=Phytochemistry |volume=28 |issue=1 |pages=193–7 |year=1989 |last1=Nishitoba |first1=Tsuyoshi |last2=Goto |first2=Sanae |last3=Sato |first3=Hiroji |last4=Sakamura |first4=Sadao }} {{closed access}}[3][4]2. ^{{cite journal |doi=10.1016/j.fitote.2014.08.004 |pmid=25111010 |title=Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities |journal=Fitoterapia |volume=98 |pages=254–9 |year=2014 |last1=Liu |first1=Li-Ying |last2=Chen |first2=Hui |last3=Liu |first3=Chao |last4=Wang |first4=Hong-Qing |last5=Kang |first5=Jie |last6=Li |first6=Yan |last7=Chen |first7=Ruo-Yun }} 3. ^1 {{Cite journal | last1 = Wang | first1 = G. | last2 = Zhao | first2 = J. | last3 = Liu | first3 = J. | last4 = Huang | first4 = Y. | last5 = Zhong | first5 = J. J. | last6 = Tang | first6 = W. | doi = 10.1016/j.intimp.2007.02.006 | title = Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo| journal = International Immunopharmacology | volume = 7 | issue = 6 | pages = 864–870 | year = 2007 | pmid = 17466920}} {{closed access}} 4. ^1 {{Cite journal | last1 = Liu | first1 = J. | last2 = Kurashiki | first2 = K. | last3 = Shimizu | first3 = K. | last4 = Kondo | first4 = R. | title = Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum| doi = 10.1016/j.bmc.2006.08.018 | journal = Bioorganic & Medicinal Chemistry | volume = 14 | issue = 24 | pages = 8654–8660| date=December 2006| pmid = 16962782}} {{closed access}} }} 5 : 5α-Reductase inhibitors|Triterpenes|Alcohols|Keto acids|Sterols |
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