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词条 GCN5L2
释义

  1. Interactions

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}} __NOTOC__Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.[1][2]

Interactions

GCN5L2 has been shown to interact with:

  • DDB1,[3]
  • Ku70,[3]
  • Ku80,[3]
  • TADA2L,[3][4]
  • TAF9,[5] and
  • Transcription initiation protein SPT3 homolog.[5][6]

References

1. ^{{cite journal | vauthors = Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL | title = Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5 | journal = Mol Cell Biol | volume = 16 | issue = 2 | pages = 593–602 | date = February 1996 | pmid = 8552087 | pmc = 231038 | doi = 10.1128/mcb.16.2.593}}
2. ^{{cite web | title = Entrez Gene: GCN5L2 GCN5 general control of amino-acid synthesis 5-like 2 (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2648| accessdate = }}
3. ^1 2 {{cite journal | vauthors = Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL | title = Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1349–58 | date = March 1998 | pmid = 9488450 | pmc = 108848 | doi = 10.1128/mcb.18.3.1349}}
4. ^{{cite journal | vauthors = Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL | title = Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation | journal = Mol. Cell. Biol. | volume = 17 | issue = 1 | pages = 519–27 | date = January 1997 | pmid = 8972232 | pmc = 231776 | doi = 10.1128/mcb.17.1.519}}
5. ^1 2 {{cite journal | vauthors = Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG | title = Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo | journal = Mol. Cell. Biol. | volume = 21 | issue = 20 | pages = 6782–95 | date = October 2001 | pmid = 11564863 | pmc = 99856 | doi = 10.1128/MCB.21.20.6782-6795.2001 }}
6. ^{{cite journal | vauthors = Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L | title = UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation | journal = EMBO J. | volume = 20 | issue = 12 | pages = 3187–96 | date = June 2001 | pmid = 11406595 | pmc = 150203 | doi = 10.1093/emboj/20.12.3187 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM | title = Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map. | journal = Nat. Genet. | volume = 10 | issue = 4 | pages = 415–23 | year = 1995 | pmid = 7670491 | doi = 10.1038/ng0895-415 }}
  • {{cite journal | vauthors = Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y | title = A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. | journal = Nature | volume = 382 | issue = 6589 | pages = 319–24 | year = 1996 | pmid = 8684459 | doi = 10.1038/382319a0 }}
  • {{cite journal | vauthors = Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL | title = Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. | journal = Mol. Cell. Biol. | volume = 17 | issue = 1 | pages = 519–27 | year = 1997 | pmid = 8972232 | pmc = 231776 | doi = 10.1128/mcb.17.1.519}}
  • {{cite journal | vauthors = Carter KC, Wang L, Shell BK, Zamir I, Berger SL, Moore PA | title = The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern. | journal = Genomics | volume = 40 | issue = 3 | pages = 497–500 | year = 1997 | pmid = 9073520 | doi = 10.1006/geno.1996.4605 }}
  • {{cite journal | vauthors = Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL | title = Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex. | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1349–58 | year = 1998 | pmid = 9488450 | pmc = 108848 | doi = 10.1128/mcb.18.3.1349}}
  • {{cite journal | vauthors = Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y, Allis CD | title = Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. | journal = Nucleic Acids Res. | volume = 26 | issue = 12 | pages = 2948–54 | year = 1998 | pmid = 9611240 | pmc = 147644 | doi = 10.1093/nar/26.12.2948 }}
  • {{cite journal | vauthors = Randhawa GS, Bell DW, Testa JR, Feinberg AP | title = Identification and mapping of human histone acetylation modifier gene homologues. | journal = Genomics | volume = 51 | issue = 2 | pages = 262–9 | year = 1998 | pmid = 9722949 | doi = 10.1006/geno.1998.5370 }}
  • {{cite journal | vauthors = Xu W, Edmondson DG, Roth SY | title = Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5659–69 | year = 1998 | pmid = 9742083 | pmc = 109152 | doi = 10.1128/MCB.18.10.5659}}
  • {{cite journal | vauthors = Brand M, Yamamoto K, Staub A, Tora L | title = Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. | journal = J. Biol. Chem. | volume = 274 | issue = 26 | pages = 18285–9 | year = 1999 | pmid = 10373431 | doi = 10.1074/jbc.274.26.18285 }}
  • {{cite journal | vauthors = McMahon SB, Wood MA, Cole MD | title = The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. | journal = Mol. Cell. Biol. | volume = 20 | issue = 2 | pages = 556–62 | year = 2000 | pmid = 10611234 | pmc = 85131 | doi = 10.1128/MCB.20.2.556-562.2000 }}
  • {{cite journal | vauthors = Kurooka H, Honjo T | title = Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 17211–20 | year = 2000 | pmid = 10747963 | doi = 10.1074/jbc.M000909200 }}
  • {{cite journal | vauthors = Hudson BP, Martinez-Yamout MA, Dyson HJ, Wright PE|authorlink3=Jane Dyson | title = Solution structure and acetyl-lysine binding activity of the GCN5 bromodomain. | journal = J. Mol. Biol. | volume = 304 | issue = 3 | pages = 355–70 | year = 2000 | pmid = 11090279 | doi = 10.1006/jmbi.2000.4207 }}
  • {{cite journal | vauthors = Col E, Caron C, Seigneurin-Berny D, Gracia J, Favier A, Khochbin S | title = The histone acetyltransferase, hGCN5, interacts with and acetylates the HIV transactivator, Tat. | journal = J. Biol. Chem. | volume = 276 | issue = 30 | pages = 28179–84 | year = 2001 | pmid = 11384967 | doi = 10.1074/jbc.M101385200 }}
  • {{cite journal | vauthors = Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L | title = UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. | journal = EMBO J. | volume = 20 | issue = 12 | pages = 3187–96 | year = 2001 | pmid = 11406595 | pmc = 150203 | doi = 10.1093/emboj/20.12.3187 }}
  • {{cite journal | vauthors = Gangloff YG, Pointud JC, Thuault S, Carré L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I | title = The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. | journal = Mol. Cell. Biol. | volume = 21 | issue = 15 | pages = 5109–21 | year = 2001 | pmid = 11438666 | pmc = 87236 | doi = 10.1128/MCB.21.15.5109-5121.2001 }}
  • {{cite journal | vauthors = Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG | title = Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. | journal = Mol. Cell. Biol. | volume = 21 | issue = 20 | pages = 6782–95 | year = 2001 | pmid = 11564863 | pmc = 99856 | doi = 10.1128/MCB.21.20.6782-6795.2001 }}
  • {{cite journal | vauthors = Yanagisawa J, Kitagawa H, Yanagida M, Wada O, Ogawa S, Nakagomi M, Oishi H, Yamamoto Y, Nagasawa H, McMahon SB, Cole MD, Tora L, Takahashi N, Kato S | title = Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 553–62 | year = 2002 | pmid = 11931763 | doi = 10.1016/S1097-2765(02)00478-1 }}
  • {{cite journal | vauthors = Brès V, Kiernan R, Emiliani S, Benkirane M | title = Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication. | journal = J. Biol. Chem. | volume = 277 | issue = 25 | pages = 22215–21 | year = 2002 | pmid = 11956210 | doi = 10.1074/jbc.M201895200 }}
  • {{cite journal | vauthors = Col E, Gilquin B, Caron C, Khochbin S | title = Tat-controlled protein acetylation. | journal = J. Biol. Chem. | volume = 277 | issue = 40 | pages = 37955–60 | year = 2002 | pmid = 12154097 | doi = 10.1074/jbc.M206694200 }}
{{refend}}

External links

  • {{FactorBook|GCN5}}
{{PDB Gallery|geneid=2648}}{{gene-17-stub}}
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