| 词条 | Choh Hao Li |
| 释义 |
| name = Choh Hao Li | image = | caption = | birth_date = {{birth date|1913|4|21|mf=y}} | birth_place = Guangzhou, China | death_date = {{death date and age|1987|11|28|1913|4|21|mf=y}} | death_place = United States | nationality = Republic of China United States | ethnicity = Chinese American | field = Biochemist | work_institution = | alma_mater = Nanjing University, University of California, Berkeley | doctoral_advisor = | doctoral_students = | known_for = Discovering and synthesizing the human pituitary growth hormone | prizes = Albert Lasker Award for Basic Medical Research (1962) | religion = }} Choh Hao Li (sometimes Cho Hao Li) ({{zh|c=李卓皓|p=Lǐ Zhuōhào}}; April 21, 1913 – November 28, 1987) was a Chinese-born U.S. biochemist who discovered, in 1966, that human pituitary growth hormone (somatotropin) consists of a chain of 256 amino acids. In 1970 he succeeded in synthesizing this hormone, the largest protein molecule synthesized up to that time. Li was born in Guangzhou and educated at the Nanjing University. In 1935 he immigrated to the US, where he took up postgraduate studies at the University of California, Berkeley and later joined the staff. He became professor in 1950. In 1955 he was elected as Academician of Academia Sinica, Republic of China. Li spent his entire academic career studying the pituitary-gland hormones. In collaboration with various co-workers, he isolated several protein hormones, including adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to increase its secretion of corticoids. In 1956, Li and his group showed that ACTH consists of 39 amino acids arranged in a specific order, and that the whole chain of the natural hormone is not necessary for its action. He isolated another pituitary hormone called melanocyte-stimulating hormone (MSH) and found that not only does this hormone produce some effects similar to those produced by ACTH, but also that part of the amino acid chain of MSH is the same as that of ACTH. References
|pmid = 11619324 |last=Cole |first=R D |publication-date=1996 |year=1996 |title=Choh Hao Li: April 21, 1913 - November 28, 1987 |volume=70 |issue= |periodical=Biographical Memoirs of the National Academy of Sciences |pages=221–39 }}
|doi = 10.1111/j.1399-3011.1988.tb01371.x |pmid = 3073145 |publication-date=Dec 1988 |last1 = Hruby |year=1988 |first1 = Victor J. |last2 = Yamashiro |first2 = Donald |title=Memorial issue in honor of Professor Choh Hao Li. Part I |volume=32 |issue=6 |periodical=Int. J. Pept. Protein Res |pages=417–598 }}
|pmid = 3286549 |last=Hruby |first=V J |publication-date=Mar 1988 |year=1988 |title=In memoriam Choh Hao Li, April 21, 1913-November 28, 1987 |volume=31 |issue=3 |periodical=Int. J. Pept. Protein Res |pages=253–4 }}
|pmid = 4599575 |publication-date=Nov 1, 1973 |year=1973 |title=Classic pages in Obstetrics and Gynecology. Interstitial cell stimulating hormone. II. Method of preparation and some physico-chemical studies, by Choh Hao Li, Miriam E. Simpson, and Herbert M. Evans. Endocrinology, vol. 27, pp. 803-808, 1940 |volume=17 |issue=5 |periodical=Am. J. Obstet. Gynecol |page=716 }}
|pmid = 4896971 |publication-date=1969 |year=1969 |title=Choh Hao Li |volume=9 |issue=1 |periodical=Triangle; the Sandoz journal of medical science |pages=41–2 |month = |author = |issn = 0041-2597 }}
|pmid = 13113828 |last=INGLE |first=D J |last2=NEZAMIS |first2=J E |last3=MORLEY |first3=E H |last4=CHOH HAO |first4=L I |publication-date=Oct 1953 |year=1953 |title=The effect of some partially purified preparations of corticotrophin upon the work performance of adrenalectomized-hypophysectomized rats |volume=14 |issue=2 |periodical=Acta Endocrinol |pages=93–8 }} External links
14 : 1913 births|1987 deaths|Chinese emigrants to the United States|Guggenheim Fellows|Nanjing University alumni|People from Panyu District|University of California, Berkeley alumni|University of California, Berkeley faculty|Members of Academia Sinica|Recipients of the Albert Lasker Award for Basic Medical Research|American scientists of Chinese descent|American biologists|Chinese biologists|Scientists from Guangdong |
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