“Germ-free animal”的意思、由来-开放百科全书

词条

Germ-free animal

释义

See also
References

Germ-free animals are animals that have no microorganisms living in or on them. Such animals are raised within germ-free isolators in order to control their exposure to viral, bacterial or parasitic agents.^[1] When known strains of bacteria or microbiota are introduced to a germ-free animal, it usually is referred to as a gnotobiotic animal, however technically speaking, germ-free animals are also gnotobiotic because the status of their microbial community is known.^[2]

Germ-free animals are used in the study of probiotic research and other animal research requiring careful control of outside contaminants that can affect the experiment.^[3] They also exhibit defects in the immune system.^[4] Because intestinal microorganisms provide additional energy to the animal by breaking down dietary fiber, germ-free animals require more food to keep the same weight than animals that are not germ-free.{{Citation needed|date=January 2017}}

References

1. ^[https://medicine.umich.edu/medschool/research/office-research/unit-laboratory-animal-medicine-ulam/research-services/germ-free-mouse-facility University of Michigan] Germ Free Animal Facility - example facility for raising germ-free animals
2. ^{{cite journal | last1 = Reyniers | first1 = J.A. | year = 1959| title = Germfree Vertebrates: Present Status | doi = 10.1111/j.1749-6632.1959.tb53091.x | journal = Annals of the New York Academy of Sciences | volume = 78 | issue = 1| page = 3 }}
3. ^Of Probiotics and Possibilities - J. Armbrecht. Dept of Bacteriology, University of Wisconsin-Madison. August 2, 2000.
4. ^{{cite journal|last1=Round|first1=JL|last2=Mazmanian|first2=SK|title=The gut microbiota shapes intestinal immune responses during health and disease.|journal=Nature Reviews. Immunology|date=May 2009|volume=9|issue=5|pages=313–23|pmid=19343057|doi=10.1038/nri2515|pmc=4095778}}

1 : Animal models

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

See also

References