| 词条 | Globoidnan A |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 442810872 | ImageFile=Globoidnan A.svg | ImageSize= | IUPACName=(2R)-(3,4-dihydroxyphenyl)-2- | OtherNames= |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=827322-48-5 | PubChem=3013628 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 26333277 | SMILES = c1cc(c(cc1C[C@H](C(=O)O)OC(=O)c2cc3cc(c(cc3c(c2)c4ccc(c(c4)O)O)O)O)O)O | InChI = 1/C26H20O10/c27-18-3-1-12(5-20(18)29)6-24(25(33)34)36-26(35)15-7-14-10-22(31)23(32)11-17(14)16(8-15)13-2-4-19(28)21(30)9-13/h1-5,7-11,24,27-32H,6H2,(H,33,34)/t24-/m1/s1 | InChIKey = DHZIDIIBBCIIEG-XMMPIXPABS | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C26H20O10/c27-18-3-1-12(5-20(18)29)6-24(25(33)34)36-26(35)15-7-14-10-22(31)23(32)11-17(14)16(8-15)13-2-4-19(28)21(30)9-13/h1-5,7-11,24,27-32H,6H2,(H,33,34)/t24-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = DHZIDIIBBCIIEG-XMMPIXPASA-N |Section2={{Chembox Properties | C=26 | H=20 | O=10 | MolarMass= | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }} Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia. The molecule has been found to weakly inhibit the action of HIV integrase (IC50 = 0.64 μM) in vitro.[1] HIV integrase is an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA. It is not known that globoidnan A inhibits the action of other retroviral integrases. References1. ^{{cite journal |vauthors=Ovenden SP, Yu J, Wan SS, etal |title=Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase |journal=Phytochemistry |volume=65 |issue=24 |pages=3255–59 |year=2004 |pmid=15561191 |doi=10.1016/j.phytochem.2004.10.006 }} {{organic-compound-stub}}{{Lignan}} 4 : Lignans|Naphthalenes|Catechols|Carboxylate esters |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。