“Gluconate 5-dehydrogenase”的意思、由来-开放百科全书

词条

Gluconate 5-dehydrogenase

释义

Structural studies
References

{{enzyme
| Name = gluconate 5-dehydrogenase
| EC_number = 1.1.1.69
| CAS_number = 9028-70-0
| IUBMB_EC_number = 1/1/1/69
| GO_code = 0008874
| image =
| width =
| caption =
}}

In enzymology, a gluconate 5-dehydrogenase ({{EC number|1.1.1.69}}) is an enzyme that catalyzes the chemical reaction

D-gluconate + NAD(P)⁺ 5-dehydro-D-gluconate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-gluconate, NAD⁺, and NADP⁺, whereas its 4 products are 5-dehydro-D-gluconate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD(P)⁺ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1VL8}}.

References

{{cite journal |author1 = Ameyama M |author2 =Adachi O | year = 1982 | title = 5-Keto-D-gluconate reductase from Gluconobacter suboxydans | journal = Methods Enzymol. | volume = 89 | pages = 198–202 | doi = 10.1016/S0076-6879(82)89035-6 | series = Methods in Enzymology | isbn = 978-0-12-181989-7 }}
{{cite journal | vauthors = Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM | year = 2006 | title = A proteomic analysis of arsenical drug resistance in Trypanosoma brucei | journal = Proteomics | volume = 6 | pages = 2726–32 | pmid = 16526094 | doi = 10.1002/pmic.200500419 | issue = 9 }}
{{cite journal | author = Okamoto K | location = Tokyo | title = Enzymic studies on the formation of 5-ketogluconic acid by Acetobacter suboxydans. II. 5-Ketogluconate reductase | journal = J. Biochem. | pages = 448–52 | pmid=13939777 | volume=53}}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of known structure

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