“Glucosaminate ammonia-lyase”的意思、由来-开放百科全书

词条

Glucosaminate ammonia-lyase

释义

References

{{enzyme
| Name = glucosaminate ammonia-lyase
| EC_number = 4.3.1.9
| CAS_number = 37290-91-8
| IUBMB_EC_number = 4/3/1/9
| GO_code = 0047930
| image =
| width =
| caption =
}}

In enzymology, a glucosaminate ammonia-lyase ({{EC number|4.3.1.9}}) is an enzyme that catalyzes the chemical reaction

D-glucosaminate 2-dehydro-3-deoxy-D-gluconate + NH₃

Hence, this enzyme has one substrate, D-glucosaminate, and two products, 2-dehydro-3-deoxy-D-gluconate and NH₃.

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is D-glucosaminate ammonia-lyase (isomerizing 2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include glucosaminic dehydrase, D-glucosaminate dehydratase, D-glucosaminic acid dehydrase, aminodeoxygluconate dehydratase, 2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating), aminodeoxygluconate ammonia-lyase, 2-amino-2-deoxy-D-gluconate ammonia-lyase, and D-glucosaminate ammonia-lyase. This enzyme participates in pentose phosphate pathway. It employs one cofactor, pyridoxal phosphate.

References

{{cite journal | author = Imanaga Y | date=1958|location = Tokyo | title = Metabolism of D-glucosamine. III. Enzymic degradation of D-glucosaminic acid | journal = J. Biochem. |volume=45| pages = 647–650 }}
{{cite book |author1 = Merrick JM |author2 =Roseman S | date = 1966 | title=Carbohydrate Metabolism|chapter = D-Glucosaminic acid dehydrase | volume = 9 | pages = 657–660 | doi = 10.1016/0076-6879(66)09133-X | series = Methods in Enzymology | isbn = 978-0-12-181809-8 }}
{{cite journal | vauthors = Iwamoto R, Imanaga Y, Soda K | date=Jan 1982|location = Tokyo | title = D-glucosaminate dehydratase from Agrobacterium radiobacter Physicochemical and enzymological properties | journal = J. Biochem. | pages = 283–9 | pmid = 7068563 | volume=91|issue = 1 }}
{{cite journal | vauthors = Iwamoto R, Taniki H, Koishi J, Nakura S | date = 1995 | title = D-glucosaminate aldolase activity of D-glucosaminate dehydratase from Pseudomonas fluorescens and its requirement for Mn2+ ion | journal = Biosci. Biotechnol. Biochem. | volume = 59 | pages = 408–11 | pmid = 7766176 | doi = 10.1271/bbb.59.408 | issue = 3 }}

3 : EC 4.3.1|Pyridoxal phosphate enzymes|Enzymes of unknown structure

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