“Glucose 1-dehydrogenase”的意思、由来-开放百科全书

词条

Glucose 1-dehydrogenase

释义

Structural studies
References

{{enzyme
| Name = glucose 1-dehydrogenase
| EC_number = 1.1.1.47
| CAS_number = 9028-53-9
| IUBMB_EC_number = 1/1/1/47
| GO_code = 0047936
| image = 1spx.jpg
| width = 270
| caption = Glucose dehydrogenase tetramer, Caenorhabditis Elegans
}}

In enzymology, a glucose 1-dehydrogenase ({{EC number|1.1.1.47}}) is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)⁺ D-glucono-1,5-lactone + NAD(P)H + H⁺

The 3 substrates of this enzyme are beta-D-glucose, NAD⁺, and NADP⁺, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)⁺ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)⁺).

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1G6K}}, {{PDB link|1GCO}}, {{PDB link|1GEE}}, {{PDB link|1RWB}}, {{PDB link|1SPX}}, {{PDB link|2B5V}}, {{PDB link|2B5W}}, {{PDB link|2CD9}}, and {{PDB link|2CDA}}.

References

{{cite journal | vauthors = Banauch D, Brümmer W, Ebeling W, Metz H, Rindfrey H, Lang H, Leybold K, Rick W, Staudinger HJ | year = 1975 | title = [A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)] | journal = Z. Klin. Chem. Klin. Biochem. | volume = 13 | pages = 101–7 | pmid = 810982 | issue = 3 }}
{{cite journal | author = Brink NG | year = 1953 | title = Beef liver glucose dehydrogenase. 1. Purification and properties | journal = Acta Chem. Scand. | volume = 7 | pages = 1081–1089 | doi = 10.3891/acta.chem.scand.07-1081 | last2 = Miettinen | first2 = Jorma K. | last3 = Olsen | first3 = John | last4 = Virtanen | first4 = Artturi I. | last5 = Sörensen | first5 = Nils Andreas }}
{{cite journal |vauthors=Pauly HE, Pfleiderer G| year = 1976 | title = D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure | journal = Hoppe-Seyler's Z. Physiol. Chem. | volume = 356 | pages = 1613–1623 | pmid=2530 | issue = 10 | doi=10.1515/bchm2.1975.356.2.1613}}
{{cite journal |vauthors=Strecker HJ, Korkes S | year = 1952 | title = Glucose dehydrogenase | journal = J. Biol. Chem. | volume = 196 | pages = 769–84 | pmid = 12981017 | issue = 2 }}
{{cite journal |vauthors=Thompson RE, Carper WR | year = 1970 | title = Glucose dehydrogenase from pig liver. I. Isolation and purification | journal = Biochim. Biophys. Acta | volume = 198 | pages = 397–406 | pmid = 4392298 | issue = 3 | doi=10.1016/0005-2744(70)90118-x}}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of known structure

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