“Glucose 1-dehydrogenase (NAD+)”的意思、由来-开放百科全书

词条

Glucose 1-dehydrogenase (NAD+)

释义

Structural studies
References

{{DISPLAYTITLE:Glucose 1-dehydrogenase (NAD⁺)}}{{enzyme
| Name = glucose 1-dehydrogenase (NAD⁺)
| EC_number = 1.1.1.118
| CAS_number = 37250-49-0
| IUBMB_EC_number = 1/1/1/118
| GO_code = 0047934
| image =
| width =
| caption =
}}

In enzymology, a glucose 1-dehydrogenase (NAD⁺) ({{EC number|1.1.1.118}}) is an enzyme that catalyzes the chemical reaction

D-glucose + NAD⁺ D-glucono-1,5-lactone + NADH + H⁺

Thus, the two substrates of this enzyme are D-glucose and NAD⁺, whereas its 3 products are D-glucono-1,5-lactone, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glucose:NAD⁺ 1-oxidoreductase. Other names in common use include D-glucose:NAD⁺ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD⁺).

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2DTD}}, {{PDB link|2DTE}}, and {{PDB link|2DTX}}.

References

{{cite journal | vauthors = Hu AS, Cline AL | title = THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD | journal = Biochimica et Biophysica Acta | volume = 93 | pages = 237–45 | date = November 1964 | pmid = 14251301 | doi = 10.1016/0304-4165(64)90371-x }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。