“Glutamate synthase (NADH)”的意思、由来-开放百科全书

词条

Glutamate synthase (NADH)

释义

Nomenclature
See also
References

{{Other uses|Glutamate synthase (disambiguation){{!}}Glutamate synthase}}{{enzyme
| Name = glutamate synthase (NADH)
| EC_number = 1.4.1.14
| CAS_number = 65589-88-0
| IUBMB_EC_number = 1/4/1/14
| GO_code = 0016040
| image =
| width =
| caption =
}}

In enzymology, a glutamate synthase (NADH) ({{EC number|1.4.1.14}}) is an enzyme that catalyzes the chemical reaction

2 L-glutamate + NAD⁺ L-glutamine + 2-oxoglutarate + NADH + H⁺

Thus, the two substrates of this enzyme are L-glutamate and NAD⁺, whereas its 4 products are L-glutamine, 2-oxoglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. This enzyme participates in glutamate metabolism and nitrogen assimilation. It employs one cofactor, FMN.

Nomenclature

The systematic name of this enzyme class is L-glutamate:NAD⁺ oxidoreductase (transaminating). Other names in common use include:

glutamate (reduced nicotinamide adenine dinucleotide) synthase,
glutamate synthase (NADH),
L-glutamate synthetase(NADH),
NADH-dependent glutamate synthase,
NADH-glutamate synthase, and
NADH-Glutamine oxoglutarate aminotransferase (NADH-GOGAT).

References

{{cite journal | vauthors = Boland MJ, Benny AG | date = 1977 | title = Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH-dependent glutamate synthase from lupin nodules | journal = Eur. J. Biochem. | volume = 79 | pages = 355–62 | pmid = 21790 | doi = 10.1111/j.1432-1033.1977.tb11816.x | issue = 2 }}

4 : EC 1.4.1|NADH-dependent enzymes|Flavin enzymes|Enzymes of unknown structure

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Nomenclature

See also

References