“Glutamate—tRNA(Gln) ligase”的意思、由来-开放百科全书

词条

Glutamate—tRNA(Gln) ligase

释义

References

{{enzyme
| Name = glutamate-tRNA(Gln) ligase
| EC_number = 6.1.1.24
| CAS_number = 9068-76-2
| IUBMB_EC_number = 6/1/1/24
| GO_code = 0050561
| image =
| width =
| caption =
}}

In enzymology, a glutamate-tRNAGln ligase ({{EC number|6.1.1.24}}) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + tRNAGlx AMP + diphosphate + glutamyl-tRNAGlx

The 3 substrates of this enzyme are ATP, L-glutamate, and tRNAGlx, whereas its 3 products are AMP, diphosphate, and glutamyl-tRNAGlx.

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlx ligase (AMP-forming). This enzyme is also called glutamyl-tRNA synthetase. This enzyme participates in glutamate metabolism.

References

{{cite journal |vauthors=Ibba M, Soll D | year = 2000 | title = Aminoacyl-tRNA synthesis | journal = Annu. Rev. Biochem. | volume = 69 | pages = 617–50 | pmid = 10966471 | doi = 10.1146/annurev.biochem.69.1.617 }}
{{cite journal |vauthors=Schmitt E, Moulinier L, Fujiwara S, Imanaka T, Thierry JC, Moras D | year = 1998 | title = Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation | journal = EMBO J. | volume = 17 | pages = 5227–37 | pmid = 9724658 | doi = 10.1093/emboj/17.17.5227 | issue = 17 | pmc = 1170850 }}
{{cite journal |vauthors=Kim SI, Soll D | year = 1998 | title = Major identity element of glutamine tRNAs from Bacillus subtilis and Escherichia coli in the reaction with B. subtilis glutamyl-tRNA synthetase | journal = Mol. Cells | volume = 8 | pages = 459–65 | pmid = 9749534 | issue = 4 }}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Glutamate-tRNA(Gln) ligase}}{{ligase-stub}}

2 : EC 6.1.1|Enzymes of unknown structure

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