“Glutamine—tRNA ligase”的意思、由来-开放百科全书

词条

Glutamine—tRNA ligase

释义

Structural studies
References

{{enzyme
| Name = glutamine-tRNA ligase
| EC_number = 6.1.1.18
| CAS_number = 9075-59-6
| IUBMB_EC_number = 6/1/1/18
| GO_code = 0004819
| image =
| width =
| caption =
}}

In enzymology, a glutamine-tRNA ligase ({{EC number|6.1.1.18}}) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamine + tRNAGln AMP + diphosphate + L-glutaminyl-tRNAGln

The 3 substrates of this enzyme are ATP, L-glutamine, and tRNA(Gln), whereas its 3 products are AMP, diphosphate, and L-glutaminyl-tRNA(Gln).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamine:tRNAGln ligase (AMP-forming). Other names in common use include glutaminyl-tRNA synthetase, glutaminyl-transfer RNA synthetase, glutaminyl-transfer ribonucleate synthetase, glutamine-tRNA synthetase, glutamine translase, glutamate-tRNA ligase, glutaminyl ribonucleic acid, and GlnRS. This enzyme participates in glutamate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1EUQ}}, {{PDB link|1EUY}}, {{PDB link|1EXD}}, {{PDB link|1GSG}}, {{PDB link|1GTR}}, {{PDB link|1GTS}}, {{PDB link|1NYL}}, {{PDB link|1O0B}}, {{PDB link|1O0C}}, {{PDB link|1QRS}}, {{PDB link|1QRT}}, {{PDB link|1QRU}}, {{PDB link|1QTQ}}, {{PDB link|1ZJW}}, and {{PDB link|2HZ7}}.

References

{{cite journal | vauthors = Ravel JM, Wang S, Heinemeyer C, Shive W | year = 1965 | title = Glutamyl and glutaminyl ribonucleic acid synthetases of Escherichia coli W. Separation, properties, and stimulation of adenosine triphosphate-pyrophosphate exchange by acceptor ribonucleic acid | journal = J. Biol. Chem. | volume = 240 | pages = 432–438 | pmid=14253448}}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{ligase-stub}}{{DEFAULTSORT:Glutamine-tRNA ligase}}

2 : EC 6.1.1|Enzymes of known structure

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